The effect of spironolactone on experimental periodontitis in rats

Morten Christian Bay Grauballe; Benny Bentzen; M Björnsson; Dennis Moe; Thomas Engelbrecht Nordkild Jonassen; K Bendtzen; Kaj Stoltze; Palle Holmstrup

doi:10.1111/j.1600-0765.2005.00792.x

The effect of spironolactone on experimental periodontitis in rats

Morten Christian Bay Grauballe, Benny Bentzen, M Björnsson, Dennis Moe, Thomas Engelbrecht Nordkild Jonassen, K Bendtzen, Kaj Stoltze, Palle Holmstrup

20 Citationer (Scopus)

Abstract

Elevated levels of tumour necrosis factor (TNF) have been found in patients with adult periodontitis. Animal studies have shown that TNF plays an important role in the pathogenesis of periodontitis. New findings suggest that the aldosterone-inhibitor spironolactone possesses an anti-TNF effect. The purpose of the study was to determine the anti-TNF effect of spironolactone in an endotoxic shock rat model and to disclose the effect of oral administration of spironolactone on the development of experimental periodontitis in rats.

Originalsprog	Engelsk
Tidsskrift	Journal of Periodontal Research
Vol/bind	40
Udgave nummer	3
Sider (fra-til)	212-7
Antal sider	6
ISSN	0022-3484
DOI	https://doi.org/10.1111/j.1600-0765.2005.00792.x
Status	Udgivet - 1 jun. 2005

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title = "The effect of spironolactone on experimental periodontitis in rats",

abstract = "Elevated levels of tumour necrosis factor (TNF) have been found in patients with adult periodontitis. Animal studies have shown that TNF plays an important role in the pathogenesis of periodontitis. New findings suggest that the aldosterone-inhibitor spironolactone possesses an anti-TNF effect. The purpose of the study was to determine the anti-TNF effect of spironolactone in an endotoxic shock rat model and to disclose the effect of oral administration of spironolactone on the development of experimental periodontitis in rats.",

author = "Grauballe, \{Morten Christian Bay\} and Benny Bentzen and M Bj{\"o}rnsson and Dennis Moe and Jonassen, \{Thomas Engelbrecht Nordkild\} and K Bendtzen and Kaj Stoltze and Palle Holmstrup",

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doi = "10.1111/j.1600-0765.2005.00792.x",

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T1 - The effect of spironolactone on experimental periodontitis in rats

AU - Grauballe, Morten Christian Bay

AU - Bentzen, Benny

AU - Björnsson, M

AU - Moe, Dennis

AU - Jonassen, Thomas Engelbrecht Nordkild

AU - Bendtzen, K

AU - Stoltze, Kaj

AU - Holmstrup, Palle

PY - 2005/6/1

Y1 - 2005/6/1

N2 - Elevated levels of tumour necrosis factor (TNF) have been found in patients with adult periodontitis. Animal studies have shown that TNF plays an important role in the pathogenesis of periodontitis. New findings suggest that the aldosterone-inhibitor spironolactone possesses an anti-TNF effect. The purpose of the study was to determine the anti-TNF effect of spironolactone in an endotoxic shock rat model and to disclose the effect of oral administration of spironolactone on the development of experimental periodontitis in rats.

AB - Elevated levels of tumour necrosis factor (TNF) have been found in patients with adult periodontitis. Animal studies have shown that TNF plays an important role in the pathogenesis of periodontitis. New findings suggest that the aldosterone-inhibitor spironolactone possesses an anti-TNF effect. The purpose of the study was to determine the anti-TNF effect of spironolactone in an endotoxic shock rat model and to disclose the effect of oral administration of spironolactone on the development of experimental periodontitis in rats.

UR - https://www.scopus.com/pages/publications/18544386495

U2 - 10.1111/j.1600-0765.2005.00792.x

DO - 10.1111/j.1600-0765.2005.00792.x

M3 - Journal article

C2 - 15853966

SN - 0022-3484

VL - 40

SP - 212

EP - 217

JO - Journal of Periodontal Research

JF - Journal of Periodontal Research

IS - 3

ER -

The effect of spironolactone on experimental periodontitis in rats

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