The effect of short-term glucagon infusion on kidney function in normal man

H H Parving, J Noer, H Kehlet, C E Mogensen, P A Svendsen, L Heding

76 Citationer (Scopus)

Abstrakt

Kidney function was studied in six normal males before and during a 2 h glucagon (10 ng/kg/min) infusion. The following variables were determined during each 20 min clearance period; glomerular filtration rate (GFR), renal plasma-flow (RPF) , filtration fraction (FF), urinary albumin and beta2-microglobulin-excretion rates. Glucagon infusion resulted in a fourfold increase in plasma glucagon concentration. The infusion induced a significant increase in GFR (+9%), FF (+9%) and urinary beta2-microglobulin excretion rate (+32%), (p less than 0.01). RPF and urinary albumin excretion rates were not significantly changed. We suggest that glucagon may contribute to the reversible kidney function alterations typically found in poorly regulated juvenile diabetes, a state with relative or absolute hyperglucagonaemia.

OriginalsprogEngelsk
TidsskriftDiabetologia
Vol/bind13
Udgave nummer4
Sider (fra-til)323-5
Antal sider3
ISSN0012-186X
StatusUdgivet - aug. 1977

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