The effect of salicylazosulphapyridine (sulphasalazine) on male fertility. A review

A Giwercman; N E Skakkebaek

doi:10.1111/j.1365-2605.1986.tb00866.x

The effect of salicylazosulphapyridine (sulphasalazine) on male fertility. A review

Abstract

Salicylazosulfapyridine (SASP), a drug used in the treatment of inflammatory bowel diseases, has been reported to depress the fertility in males. Therefore, some authors have proposed SASP as a new lead in the search for a contraceptive for men. Based on a review of the literature, our conclusion is that SASP taken in tolerable doses has not sufficient antifertility effect. Additionally, the drug has too serious and too many side effects to be accepted as a contraceptive. However, the effect on male fertility of other sulfa drugs and related compounds remains to be investigated.

Originalsprog	Engelsk
Tidsskrift	International Journal of Andrology
Vol/bind	9
Udgave nummer	1
Sider (fra-til)	38-52
Antal sider	15
ISSN	0105-6263
DOI	https://doi.org/10.1111/j.1365-2605.1986.tb00866.x
Status	Udgivet - feb. 1986
Udgivet eksternt	Ja

Adgang til dokumentet

10.1111/j.1365-2605.1986.tb00866.x

Citationsformater

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title = "The effect of salicylazosulphapyridine (sulphasalazine) on male fertility. A review",

abstract = "Salicylazosulfapyridine (SASP), a drug used in the treatment of inflammatory bowel diseases, has been reported to depress the fertility in males. Therefore, some authors have proposed SASP as a new lead in the search for a contraceptive for men. Based on a review of the literature, our conclusion is that SASP taken in tolerable doses has not sufficient antifertility effect. Additionally, the drug has too serious and too many side effects to be accepted as a contraceptive. However, the effect on male fertility of other sulfa drugs and related compounds remains to be investigated.",

keywords = "Acrosome/drug effects, Animals, Bulbourethral Glands/drug effects, Chemical Phenomena, Chemistry, Contraceptive Agents, Male/administration & dosage, Contraceptives, Oral, Disease Models, Animal, Drug Interactions, Fertility/drug effects, Folic Acid/metabolism, Hormones/metabolism, Humans, Male, Sulfasalazine/administration & dosage, Testis/drug effects",

author = "A Giwercman and Skakkebaek, {N E}",

year = "1986",

month = feb,

doi = "10.1111/j.1365-2605.1986.tb00866.x",

language = "English",

volume = "9",

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journal = "International Journal of Andrology",

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TY - JOUR

T1 - The effect of salicylazosulphapyridine (sulphasalazine) on male fertility. A review

AU - Giwercman, A

AU - Skakkebaek, N E

PY - 1986/2

Y1 - 1986/2

N2 - Salicylazosulfapyridine (SASP), a drug used in the treatment of inflammatory bowel diseases, has been reported to depress the fertility in males. Therefore, some authors have proposed SASP as a new lead in the search for a contraceptive for men. Based on a review of the literature, our conclusion is that SASP taken in tolerable doses has not sufficient antifertility effect. Additionally, the drug has too serious and too many side effects to be accepted as a contraceptive. However, the effect on male fertility of other sulfa drugs and related compounds remains to be investigated.

AB - Salicylazosulfapyridine (SASP), a drug used in the treatment of inflammatory bowel diseases, has been reported to depress the fertility in males. Therefore, some authors have proposed SASP as a new lead in the search for a contraceptive for men. Based on a review of the literature, our conclusion is that SASP taken in tolerable doses has not sufficient antifertility effect. Additionally, the drug has too serious and too many side effects to be accepted as a contraceptive. However, the effect on male fertility of other sulfa drugs and related compounds remains to be investigated.

KW - Acrosome/drug effects

KW - Animals

KW - Bulbourethral Glands/drug effects

KW - Chemical Phenomena

KW - Chemistry

KW - Contraceptive Agents, Male/administration & dosage

KW - Contraceptives, Oral

KW - Disease Models, Animal

KW - Drug Interactions

KW - Fertility/drug effects

KW - Folic Acid/metabolism

KW - Hormones/metabolism

KW - Humans

KW - Male

KW - Sulfasalazine/administration & dosage

KW - Testis/drug effects

U2 - 10.1111/j.1365-2605.1986.tb00866.x

DO - 10.1111/j.1365-2605.1986.tb00866.x

M3 - Review

C2 - 2875031

SN - 0105-6263

VL - 9

SP - 38

EP - 52

JO - International Journal of Andrology

JF - International Journal of Andrology

IS - 1

ER -

The effect of salicylazosulphapyridine (sulphasalazine) on male fertility. A review

Abstract

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