TY - JOUR
T1 - The effect of saffron supplementation on glycemic parameters
T2 - An overview of systematic reviews
AU - Sadigi, Behnam
AU - Yarani, Reza
AU - Mirghafourvand, Mojgan
AU - Travica, Nikolaj
AU - Yousefi, Zahra
AU - Shakouri, Seyed Kazem
AU - Ostadrahimi, Alireza
AU - Mobasseri, Majid
AU - Pociot, Flemming
AU - Sanaie, Sarvin
AU - Araj-Khodaei, Mostafa
N1 - © 2022 John Wiley & Sons Ltd.
PY - 2022/9
Y1 - 2022/9
N2 - Due to the widespread use of herbal medicine and evidence pointing to the health benefits of saffron supplementation, this review was performed to evaluate the effects of saffron supplementation on glycemic parameters and lipid profiles based on previous reviews. Relevant articles were retrieved from various databases, which included PubMed, Scopus, ProQuest, Web of Science, Embase, and Cochrane until 2020, with no date restrictions. The quality of the included reviews was assessed using the Assessment of Multiple Systematic Reviews (AMSTAR) checklist. Finally, of 877 obtained articles, eight reviews meeting the inclusion criteria were included for analysis. Among the eight included reviews, seven articles were meta-analyses. In addition, one review had an average quality while seven had a good quality. A narrative description of the included reviews was performed, while a network meta-analysis was not conducted. A brief review of the results was reported according to the weighted mean difference and mean difference. Seven included reviews assessed the effects of saffron or crocin supplementation on glycemic parameters, and six examined these effects on lipid profile parameters. Almost half of the articles reported significant effects of these supplements on glycemic parameters and lipid profiles. Taken together, results suggest that saffron supplementation may improve glycemic and lipid profile parameters; however, further high-quality studies are needed to confirm the clinical efficacy of saffron on glycemic parameters and lipid profiles.
AB - Due to the widespread use of herbal medicine and evidence pointing to the health benefits of saffron supplementation, this review was performed to evaluate the effects of saffron supplementation on glycemic parameters and lipid profiles based on previous reviews. Relevant articles were retrieved from various databases, which included PubMed, Scopus, ProQuest, Web of Science, Embase, and Cochrane until 2020, with no date restrictions. The quality of the included reviews was assessed using the Assessment of Multiple Systematic Reviews (AMSTAR) checklist. Finally, of 877 obtained articles, eight reviews meeting the inclusion criteria were included for analysis. Among the eight included reviews, seven articles were meta-analyses. In addition, one review had an average quality while seven had a good quality. A narrative description of the included reviews was performed, while a network meta-analysis was not conducted. A brief review of the results was reported according to the weighted mean difference and mean difference. Seven included reviews assessed the effects of saffron or crocin supplementation on glycemic parameters, and six examined these effects on lipid profile parameters. Almost half of the articles reported significant effects of these supplements on glycemic parameters and lipid profiles. Taken together, results suggest that saffron supplementation may improve glycemic and lipid profile parameters; however, further high-quality studies are needed to confirm the clinical efficacy of saffron on glycemic parameters and lipid profiles.
KW - Blood Glucose
KW - Crocus
KW - Dietary Supplements
KW - Lipids
KW - Systematic Reviews as Topic
UR - http://www.scopus.com/inward/record.url?scp=85133175249&partnerID=8YFLogxK
U2 - 10.1002/ptr.7542
DO - 10.1002/ptr.7542
M3 - Review
C2 - 35778993
VL - 36
SP - 3444
EP - 3458
JO - Phytotherapy Research
JF - Phytotherapy Research
SN - 0951-418X
IS - 9
ER -