The effect of phenylephrine on arterial and venous cerebral blood flow in healthy subjects

Shigehiko Ogoh; Kohei Sato; James P Fisher; Thomas Seifert; Morten Overgaard; Niels H Secher

doi:10.1111/j.1475-097X.2011.01040.x

The effect of phenylephrine on arterial and venous cerebral blood flow in healthy subjects

Shigehiko Ogoh, Kohei Sato, James P Fisher, Thomas Seifert, Morten Overgaard, Niels H Secher

85 Citationer (Scopus)

Abstract

Sympathetic regulation of the cerebral circulation remains controversial. Although intravenous phenylephrine (PE) infusion reduces the near-infrared spectroscopy (NIRS)-determined measure of frontal lobe oxygenation (S(c) O(2) ) and increases middle cerebral artery mean blood velocity (MCA V(mean) ), suggesting α-adrenergic-mediated cerebral vasoconstriction, this remains unconfirmed by evaluation of arterial and venous cerebral blood flow.

Originalsprog	Engelsk
Tidsskrift	Clinical Physiology and Functional Imaging
Vol/bind	31
Udgave nummer	6
Sider (fra-til)	445-51
Antal sider	7
ISSN	1475-0961
DOI	https://doi.org/10.1111/j.1475-097X.2011.01040.x
Status	Udgivet - 2011

Adgang til dokumentet

10.1111/j.1475-097X.2011.01040.x

Citationsformater

@article{d19f0219fa584dd698a3525c914035e5,

title = "The effect of phenylephrine on arterial and venous cerebral blood flow in healthy subjects",

abstract = "Sympathetic regulation of the cerebral circulation remains controversial. Although intravenous phenylephrine (PE) infusion reduces the near-infrared spectroscopy (NIRS)-determined measure of frontal lobe oxygenation (S(c) O(2) ) and increases middle cerebral artery mean blood velocity (MCA V(mean) ), suggesting α-adrenergic-mediated cerebral vasoconstriction, this remains unconfirmed by evaluation of arterial and venous cerebral blood flow.",

author = "Shigehiko Ogoh and Kohei Sato and Fisher, {James P} and Thomas Seifert and Morten Overgaard and Secher, {Niels H}",

note = "{\textcopyright} 2011 The Authors. Clinical Physiology and Functional Imaging {\textcopyright} 2011 Scandinavian Society of Clinical Physiology and Nuclear Medicine.",

year = "2011",

doi = "10.1111/j.1475-097X.2011.01040.x",

language = "English",

volume = "31",

pages = "445--51",

journal = "Clinical Physiology and Functional Imaging",

issn = "1475-0961",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "6",

}

TY - JOUR

T1 - The effect of phenylephrine on arterial and venous cerebral blood flow in healthy subjects

AU - Ogoh, Shigehiko

AU - Sato, Kohei

AU - Fisher, James P

AU - Seifert, Thomas

AU - Overgaard, Morten

AU - Secher, Niels H

PY - 2011

Y1 - 2011

N2 - Sympathetic regulation of the cerebral circulation remains controversial. Although intravenous phenylephrine (PE) infusion reduces the near-infrared spectroscopy (NIRS)-determined measure of frontal lobe oxygenation (S(c) O(2) ) and increases middle cerebral artery mean blood velocity (MCA V(mean) ), suggesting α-adrenergic-mediated cerebral vasoconstriction, this remains unconfirmed by evaluation of arterial and venous cerebral blood flow.

AB - Sympathetic regulation of the cerebral circulation remains controversial. Although intravenous phenylephrine (PE) infusion reduces the near-infrared spectroscopy (NIRS)-determined measure of frontal lobe oxygenation (S(c) O(2) ) and increases middle cerebral artery mean blood velocity (MCA V(mean) ), suggesting α-adrenergic-mediated cerebral vasoconstriction, this remains unconfirmed by evaluation of arterial and venous cerebral blood flow.

U2 - 10.1111/j.1475-097X.2011.01040.x

DO - 10.1111/j.1475-097X.2011.01040.x

M3 - Journal article

C2 - 21981455

SN - 1475-0961

VL - 31

SP - 445

EP - 451

JO - Clinical Physiology and Functional Imaging

JF - Clinical Physiology and Functional Imaging

IS - 6

ER -

The effect of phenylephrine on arterial and venous cerebral blood flow in healthy subjects

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater