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The Effect of Overweight and Obesity on Liver Biochemical Markers in Children and Adolescents

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Johansen, Magnus J ; Gade, Julie ; Stender, Stefan ; Frithioff-Bøjsøe, Christine ; Lund, Morten A V ; Chabanova, Elizaveta ; Thomsen, Henrik S ; Pedersen, Oluf ; Fonvig, Cilius E ; Hansen, Torben ; Holm, Jens-Christian. / The Effect of Overweight and Obesity on Liver Biochemical Markers in Children and Adolescents. I: The Journal of clinical endocrinology and metabolism. 2020 ; Bind 105, Nr. 2. s. 430-442.

Bibtex

@article{c65fca084696436d9da9276e74842b3b,
title = "The Effect of Overweight and Obesity on Liver Biochemical Markers in Children and Adolescents",
abstract = "BACKGROUND: Elevated plasma concentrations of liver enzymes are routinely used as markers of liver injury in adults and children. Currently, the age- and sex-specific effects of adiposity on pediatric liver enzyme concentrations are unclear.METHODS: We included participants from 2 cohorts of Danish children and adolescents: 1858 from a population-based cohort and 2155 with overweight or obesity, aged from 6 to 18 years. Age- and sex-specific percentile curves were calculated for fasting plasma concentrations of alanine transaminase (ALT), aspartate transaminase (AST), lactate dehydrogenase (LDH), gamma-glutamyltransferase (GGT), bilirubin, and alkaline phosphatase (ALP) in both cohorts. Hepatic fat content was assessed by proton magnetic resonance spectroscopy in 458 participants.RESULTS: Concentrations of ALT, AST, LDH, and ALP decreased with age in both girls and boys, while GGT and bilirubin were comparable across age groups in girls and increased slightly with age in boys. Children and adolescents with overweight or obesity exhibited higher concentrations of ALT in all age groups. Concentrations of ALT, and to a lesser degree GGT, increased with age in boys with overweight or obesity. Optimal ALT cut-points for diagnosing hepatic steatosis (liver fat content > 5%) was 24.5 U/L for girls (sensitivity: 55.6%, specificity: 84.0%), and 34.5 U/L for boys (sensitivity: 83.7%, specificity: 68.2%).CONCLUSIONS: Pediatric normal values of liver enzymes vary with both age and sex. Overweight and obesity is associated with elevated biochemical markers of liver damage. These findings emphasize the need for prevention and treatment of overweight and obesity in children and adolescents. (J Clin Endocrinol Metab XX: 0-0, 2019).",
keywords = "cross-sectional study, liver enzymes, obesity, pediatric, reference values",
author = "Johansen, {Magnus J} and Julie Gade and Stefan Stender and Christine Frithioff-B{\o}js{\o}e and Lund, {Morten A V} and Elizaveta Chabanova and Thomsen, {Henrik S} and Oluf Pedersen and Fonvig, {Cilius E} and Torben Hansen and Jens-Christian Holm",
note = "Published by Oxford University Press on behalf of the Endocrine Society 2019.",
year = "2020",
month = feb,
day = "1",
doi = "10.1210/clinem/dgz010",
language = "English",
volume = "105",
pages = "430--442",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The/Endocrine Society",
number = "2",

}

RIS

TY - JOUR

T1 - The Effect of Overweight and Obesity on Liver Biochemical Markers in Children and Adolescents

AU - Johansen, Magnus J

AU - Gade, Julie

AU - Stender, Stefan

AU - Frithioff-Bøjsøe, Christine

AU - Lund, Morten A V

AU - Chabanova, Elizaveta

AU - Thomsen, Henrik S

AU - Pedersen, Oluf

AU - Fonvig, Cilius E

AU - Hansen, Torben

AU - Holm, Jens-Christian

N1 - Published by Oxford University Press on behalf of the Endocrine Society 2019.

PY - 2020/2/1

Y1 - 2020/2/1

N2 - BACKGROUND: Elevated plasma concentrations of liver enzymes are routinely used as markers of liver injury in adults and children. Currently, the age- and sex-specific effects of adiposity on pediatric liver enzyme concentrations are unclear.METHODS: We included participants from 2 cohorts of Danish children and adolescents: 1858 from a population-based cohort and 2155 with overweight or obesity, aged from 6 to 18 years. Age- and sex-specific percentile curves were calculated for fasting plasma concentrations of alanine transaminase (ALT), aspartate transaminase (AST), lactate dehydrogenase (LDH), gamma-glutamyltransferase (GGT), bilirubin, and alkaline phosphatase (ALP) in both cohorts. Hepatic fat content was assessed by proton magnetic resonance spectroscopy in 458 participants.RESULTS: Concentrations of ALT, AST, LDH, and ALP decreased with age in both girls and boys, while GGT and bilirubin were comparable across age groups in girls and increased slightly with age in boys. Children and adolescents with overweight or obesity exhibited higher concentrations of ALT in all age groups. Concentrations of ALT, and to a lesser degree GGT, increased with age in boys with overweight or obesity. Optimal ALT cut-points for diagnosing hepatic steatosis (liver fat content > 5%) was 24.5 U/L for girls (sensitivity: 55.6%, specificity: 84.0%), and 34.5 U/L for boys (sensitivity: 83.7%, specificity: 68.2%).CONCLUSIONS: Pediatric normal values of liver enzymes vary with both age and sex. Overweight and obesity is associated with elevated biochemical markers of liver damage. These findings emphasize the need for prevention and treatment of overweight and obesity in children and adolescents. (J Clin Endocrinol Metab XX: 0-0, 2019).

AB - BACKGROUND: Elevated plasma concentrations of liver enzymes are routinely used as markers of liver injury in adults and children. Currently, the age- and sex-specific effects of adiposity on pediatric liver enzyme concentrations are unclear.METHODS: We included participants from 2 cohorts of Danish children and adolescents: 1858 from a population-based cohort and 2155 with overweight or obesity, aged from 6 to 18 years. Age- and sex-specific percentile curves were calculated for fasting plasma concentrations of alanine transaminase (ALT), aspartate transaminase (AST), lactate dehydrogenase (LDH), gamma-glutamyltransferase (GGT), bilirubin, and alkaline phosphatase (ALP) in both cohorts. Hepatic fat content was assessed by proton magnetic resonance spectroscopy in 458 participants.RESULTS: Concentrations of ALT, AST, LDH, and ALP decreased with age in both girls and boys, while GGT and bilirubin were comparable across age groups in girls and increased slightly with age in boys. Children and adolescents with overweight or obesity exhibited higher concentrations of ALT in all age groups. Concentrations of ALT, and to a lesser degree GGT, increased with age in boys with overweight or obesity. Optimal ALT cut-points for diagnosing hepatic steatosis (liver fat content > 5%) was 24.5 U/L for girls (sensitivity: 55.6%, specificity: 84.0%), and 34.5 U/L for boys (sensitivity: 83.7%, specificity: 68.2%).CONCLUSIONS: Pediatric normal values of liver enzymes vary with both age and sex. Overweight and obesity is associated with elevated biochemical markers of liver damage. These findings emphasize the need for prevention and treatment of overweight and obesity in children and adolescents. (J Clin Endocrinol Metab XX: 0-0, 2019).

KW - cross-sectional study

KW - liver enzymes

KW - obesity

KW - pediatric

KW - reference values

U2 - 10.1210/clinem/dgz010

DO - 10.1210/clinem/dgz010

M3 - Journal article

C2 - 31617910

VL - 105

SP - 430

EP - 442

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 2

ER -

ID: 59410500