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The Effect of N-3 Polyunsaturated Fatty Acids on Lung Funktion and use of Medication in Athletes with Asthma. A pilot Trial.

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Asthma is the most frequent chronic disease among young adulsts,not least in the western societies, with an even higher frequency among elite athletes. Asthma consists of airway inflammation and smooth muscle contraction, normally treated with anti-asthma therapy, some of which have side effects. n-3 LCPUFA in fish oil (FO) has anti-inflammatory effects, and some studies have shown clinical effects of FO on asthma. We aimed to study if FO has an anti-asthma effect in elite athletes with asthma.
The study was a rondomized, double-blinded clinical trial. Ten elite athletes with a medical certificate allowing the use of asthma medication, age 15-36 years, were requited among elite athletes supported by the Team Denmark Organization. All subjects had a positive mannitol test prior to enrollment. Depending on whether they used inhaled corticosteroids or not, the subjects were randomly assigned in pairs to either FO (2 g EPA nad 1.3 g DHA) or soy oil capules (O) for 8 weeks. Change in forced expiratory volume (FEV1) after exercise, NO excretion, sputum cell count and use of medication were measured before and after intervention.
The was a slight trend towards increased exercised-induced decrease in lung function, use of asthma medication and respiratory inflammation in the FO-group, but the changes wre neither significant nor clinically relevant.
TidsskriftAnnals of Sports Medicine and Research
Vol/bind1 (2)
Udgave nummer1009
StatusUdgivet - dec. 2014

ID: 44829599