@article{274f3aac52094e53b3fff49255f713df,
title = "The effect of melatonin on sleep quality after laparoscopic cholecystectomy: a randomized, placebo-controlled trial",
abstract = "BACKGROUND: In this study, we investigated whether melatonin administration could improve postoperative subjective sleep quality and reduce discomfort. METHODS: One hundred twenty-one patients scheduled for elective ambulatory laparoscopic cholecystectomy were randomized to oral 5 mg melatonin (n = 60) or placebo (n = 61) for 3 nights after surgery. Subjective sleep quality, sleep duration, sleep timing, and subjective discomfort (fatigue, general well-being, and pain) were measured. RESULTS: Sleep latency was significantly reduced in the melatonin group (mean [sd] 14 min [18]) compared with placebo (28 min [41]) on the first postoperative night (P = 0.015). The rest of the measured outcome variables did not differ between groups. CONCLUSIONS: Melatonin did not improve subjective sleep quality or discomfort compared with placebo after laparoscopic cholecystectomy.",
keywords = "Administration, Oral, Adult, Ambulatory Surgical Procedures, Cholecystectomy, Laparoscopic, Double-Blind Method, Drug Administration Schedule, Fatigue, Female, Humans, Hypnotics and Sedatives, Male, Melatonin, Middle Aged, Pain Measurement, Pain, Postoperative, Sleep, Surgical Procedures, Elective, Time Factors, Treatment Outcome",
author = "Ismail G{\"o}genur and B{\"u}lent K{\"u}c{\"u}kakin and Thue Bisgaard and Viggo Kristiansen and Niels-Christian Hjorts{\o} and Skene, {Debra J} and Jacob Rosenberg",
year = "2009",
doi = "10.1213/ane.0b013e31819a6cf0",
language = "English",
volume = "108",
pages = "1152--6",
journal = "Anesthesia and Analgesia",
issn = "0003-2999",
publisher = "Lippincott Williams and Wilkins",
number = "4",
}