The effect of interleukin-1 on the thyroid gland

A K Rasmussen; U Feldt-Rasmussen; K Bendtzen

doi:10.3109/08916939308993319

The effect of interleukin-1 on the thyroid gland

A K Rasmussen, U Feldt-Rasmussen, K Bendtzen

43 Citationer (Scopus)

Abstract

The inhibitory effect of interleukin (IL)-1 on thyroid cell functions, including cAMP and thyroglobulin production, is well documented. Recently, IL-1 was shown to enhance the production of IL-6 from thyrocytes, and IL-1 receptors were demonstrated on normal thyroid cells. The origin of IL-1 could be from infiltrating monocytes/-macrophages, endothelial cells as well as from the thyrocytes themselves. Thus, IL-1 activated thyrocyte may participate directly in the immunological process by reacting to and producing immunoinflammatory cytokines.

Originalsprog	Engelsk
Tidsskrift	Autoimmunity
Vol/bind	16
Udgave nummer	2
Sider (fra-til)	141-8
Antal sider	8
ISSN	0891-6934
DOI	https://doi.org/10.3109/08916939308993319
Status	Udgivet - 1993
Udgivet eksternt	Ja

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10.3109/08916939308993319

Citationsformater

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title = "The effect of interleukin-1 on the thyroid gland",

abstract = "The inhibitory effect of interleukin (IL)-1 on thyroid cell functions, including cAMP and thyroglobulin production, is well documented. Recently, IL-1 was shown to enhance the production of IL-6 from thyrocytes, and IL-1 receptors were demonstrated on normal thyroid cells. The origin of IL-1 could be from infiltrating monocytes/-macrophages, endothelial cells as well as from the thyrocytes themselves. Thus, IL-1 activated thyrocyte may participate directly in the immunological process by reacting to and producing immunoinflammatory cytokines.",

keywords = "Animals, Cell Division/drug effects, Cells, Cultured, Cyclic AMP/biosynthesis, Humans, Interleukin-1/pharmacology, Interleukin-6/biosynthesis, Islets of Langerhans/drug effects, Male, Mice, Pituitary Gland/drug effects, Rats, Recombinant Proteins/pharmacology, Thyroid Gland/drug effects, Thyroiditis, Autoimmune/physiopathology",

author = "Rasmussen, {A K} and U Feldt-Rasmussen and K Bendtzen",

year = "1993",

doi = "10.3109/08916939308993319",

language = "English",

volume = "16",

pages = "141--8",

journal = "Autoimmunity",

issn = "0891-6934",

publisher = "Informa Healthcare",

number = "2",

}

TY - JOUR

T1 - The effect of interleukin-1 on the thyroid gland

AU - Rasmussen, A K

AU - Feldt-Rasmussen, U

AU - Bendtzen, K

PY - 1993

Y1 - 1993

N2 - The inhibitory effect of interleukin (IL)-1 on thyroid cell functions, including cAMP and thyroglobulin production, is well documented. Recently, IL-1 was shown to enhance the production of IL-6 from thyrocytes, and IL-1 receptors were demonstrated on normal thyroid cells. The origin of IL-1 could be from infiltrating monocytes/-macrophages, endothelial cells as well as from the thyrocytes themselves. Thus, IL-1 activated thyrocyte may participate directly in the immunological process by reacting to and producing immunoinflammatory cytokines.

AB - The inhibitory effect of interleukin (IL)-1 on thyroid cell functions, including cAMP and thyroglobulin production, is well documented. Recently, IL-1 was shown to enhance the production of IL-6 from thyrocytes, and IL-1 receptors were demonstrated on normal thyroid cells. The origin of IL-1 could be from infiltrating monocytes/-macrophages, endothelial cells as well as from the thyrocytes themselves. Thus, IL-1 activated thyrocyte may participate directly in the immunological process by reacting to and producing immunoinflammatory cytokines.

KW - Animals

KW - Cell Division/drug effects

KW - Cells, Cultured

KW - Cyclic AMP/biosynthesis

KW - Humans

KW - Interleukin-1/pharmacology

KW - Interleukin-6/biosynthesis

KW - Islets of Langerhans/drug effects

KW - Male

KW - Mice

KW - Pituitary Gland/drug effects

KW - Rats

KW - Recombinant Proteins/pharmacology

KW - Thyroid Gland/drug effects

KW - Thyroiditis, Autoimmune/physiopathology

U2 - 10.3109/08916939308993319

DO - 10.3109/08916939308993319

M3 - Review

C2 - 8180318

SN - 0891-6934

VL - 16

SP - 141

EP - 148

JO - Autoimmunity

JF - Autoimmunity

IS - 2

ER -

The effect of interleukin-1 on the thyroid gland

Abstract

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