The Effect of High Dose Cholecalciferol on Arterial Stiffness and Peripheral and Central Blood Pressure in Healthy Humans: A Randomized Controlled Trial

Iain Bressendorff, Lisbet Brandi, Morten Schou, Birgitte Nygaard, Niels Erik Frandsen, Knud Rasmussen, Lars Ødum, Ove Vyff Østergaard, Ditte Hansen

30 Citationer (Scopus)

Abstract

BACKGROUND: Low levels of serum 25-hydroxy vitamin D are associated with increased arterial stiffness and hypertension. Supplementation with vitamin D precursors has been proposed as a treatment option for these conditions. We examined the effect of oral cholecalciferol on arterial stiffness and blood pressure in healthy normotensive adults.

METHODS: 40 healthy adults were randomised in this double-blinded study to either oral cholecalciferol 3000 IU/day or matching placebo and were followed for 16 weeks to examine any effects on pulse wave velocity (PWV), augmentation index (AIx), peripheral and central blood pressure and 24-hour ambulatory blood pressure.

RESULTS: 22 subjects in the cholecalciferol arm and 18 subjects in the placebo arm completed the 16 weeks of follow-up. There was no difference in changes in PWV, AIx corrected for heart rate or central or peripheral blood pressure between the two groups. There was no correlation between serum 25-hydroxy vitamin D and any of these parameters.

CONCLUSIONS: Oral cholecalciferol 3000 IU/day does not affect arterial stiffness or blood pressure after 16 weeks of treatment in healthy normotensive adults.

TRIAL REGISTRATION: ClinicalTrials.gov NCT00952562.

OriginalsprogEngelsk
TidsskriftP L o S One
Vol/bind11
Udgave nummer8
Sider (fra-til)e0160905
Antal sider12
ISSN1932-6203
DOI
StatusUdgivet - 2016

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