Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

The effect of gender on early colonic anastomotic wound healing

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. The prognostic value of tumour stroma ratio and tumour budding in stage II colon cancer. A nationwide population-based study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Emergency admissions for complicated colonic diverticulitis are increasing: a nationwide register-based cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. One decade of rectal prolapse surgery: a national study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Open ventral hernia repair with a composite ventral patch - final results of a multicenter prospective study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Large Incisional Hernias Increase in Size

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Anastomotic Leakage After Stoma Reversal Combined with Incisional Hernia Repair

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

PURPOSE: Clinically, male patients subjected to colorectal surgery are more prone to develop anastomotic leakage than female patients by unknown mechanisms. Our aim was to investigate the impact of gender on anastomotic wound healing using an experimental model.

METHODS: One-layer colonic anastomosis was constructed in 8-week-old 28 male and 32 female Sprague-Dawley rats. Animals of one group (n = 30) were sacrificed immediately after surgery day 0 and the other group (n = 30) on postoperative day 3. Anastomotic breaking strength, total collagen (hydroxyproline), soluble collagen (Sircol), matrix metalloproteinase (MMP)-9, and transforming growth factor (TGF)-β1 were measured.

RESULTS: The anastomotic breaking strength decreased from day 0 to day 3 with no significant gender differences either in the extent of decline (P = 0.122) or absolute day 3 strengths (P = 0.425). Analogously, total collagen concentration in the anastomotic wounds decreased postoperatively and were lower (P = 0.043) in the male compared with the female rats on day 3. MMP-9 levels increased in the anastomoses postoperatively, but they did not differ (P = 0.391) between male and female animals. Soluble collagen levels were lower in the day-3 anastomoses of male versus female rats (P = 0.015) and correlated positively with total TGF-β1 levels (rS = 0.540, P = 0.006). Although TGF-β1 tended to be lower in male compared with the female rats, the differences did not reach statistical significance.

CONCLUSION: Our findings point towards a less favorable collagen metabolism in colonic anastomoses of male compared with female rats during early wound healing.

OriginalsprogEngelsk
TidsskriftInternational Journal of Colorectal Disease
Vol/bind33
Udgave nummer9
Sider (fra-til)1269-1276
Antal sider8
ISSN0179-1958
DOI
StatusUdgivet - sep. 2018

ID: 55452201