The effect of beta-interferon therapy on myelin basic protein-elicited CD4+ T cell proliferation and cytokine production in multiple sclerosis

Chris J Hedegaard; Martin Krakauer; Klaus Bendtzen; Per Soelberg Sørensen; Finn Sellebjerg; Claus H Nielsen

doi:10.1016/j.clim.2008.06.007

The effect of beta-interferon therapy on myelin basic protein-elicited CD4+ T cell proliferation and cytokine production in multiple sclerosis

Chris J Hedegaard, Martin Krakauer, Klaus Bendtzen, Per Soelberg Sørensen, Finn Sellebjerg, Claus H Nielsen

Afdeling for Hjerne- og Nervesygdomme

13 Citationer (Scopus)

Abstract

Interferon (IFN)-beta therapy has well-established clinical benefits in multiple sclerosis (MS), but the underlying modulation of cytokine responses to myelin self-antigens remains poorly understood. We analysed the CD4+ T cell proliferation and cytokine responses elicited by myelin basic protein (MBP) and a foreign recall antigen, tetanus toxoid (TT), in mononuclear cell cultures from fourteen MS patients undergoing IFN-beta therapy. The MBP-elicited IFN-gamma-, TNF-alpha- and IL-10 production decreased during therapy (p

Originalsprog	Engelsk
Tidsskrift	Clinical Immunology
Vol/bind	129
Udgave nummer	1
Sider (fra-til)	80-9
Antal sider	10
ISSN	1521-6616
DOI	https://doi.org/10.1016/j.clim.2008.06.007
Status	Udgivet - 1 okt. 2008

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10.1016/j.clim.2008.06.007

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title = "The effect of beta-interferon therapy on myelin basic protein-elicited CD4+ T cell proliferation and cytokine production in multiple sclerosis",

abstract = "Interferon (IFN)-beta therapy has well-established clinical benefits in multiple sclerosis (MS), but the underlying modulation of cytokine responses to myelin self-antigens remains poorly understood. We analysed the CD4+ T cell proliferation and cytokine responses elicited by myelin basic protein (MBP) and a foreign recall antigen, tetanus toxoid (TT), in mononuclear cell cultures from fourteen MS patients undergoing IFN-beta therapy. The MBP-elicited IFN-gamma-, TNF-alpha- and IL-10 production decreased during therapy (p",

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T1 - The effect of beta-interferon therapy on myelin basic protein-elicited CD4+ T cell proliferation and cytokine production in multiple sclerosis

AU - Hedegaard, Chris J

AU - Krakauer, Martin

AU - Bendtzen, Klaus

AU - Sørensen, Per Soelberg

AU - Sellebjerg, Finn

AU - Nielsen, Claus H

PY - 2008/10/1

Y1 - 2008/10/1

N2 - Interferon (IFN)-beta therapy has well-established clinical benefits in multiple sclerosis (MS), but the underlying modulation of cytokine responses to myelin self-antigens remains poorly understood. We analysed the CD4+ T cell proliferation and cytokine responses elicited by myelin basic protein (MBP) and a foreign recall antigen, tetanus toxoid (TT), in mononuclear cell cultures from fourteen MS patients undergoing IFN-beta therapy. The MBP-elicited IFN-gamma-, TNF-alpha- and IL-10 production decreased during therapy (p

AB - Interferon (IFN)-beta therapy has well-established clinical benefits in multiple sclerosis (MS), but the underlying modulation of cytokine responses to myelin self-antigens remains poorly understood. We analysed the CD4+ T cell proliferation and cytokine responses elicited by myelin basic protein (MBP) and a foreign recall antigen, tetanus toxoid (TT), in mononuclear cell cultures from fourteen MS patients undergoing IFN-beta therapy. The MBP-elicited IFN-gamma-, TNF-alpha- and IL-10 production decreased during therapy (p

U2 - 10.1016/j.clim.2008.06.007

DO - 10.1016/j.clim.2008.06.007

M3 - Journal article

C2 - 18653385

SN - 1521-6616

VL - 129

SP - 80

EP - 89

JO - Clinical Immunology

JF - Clinical Immunology

IS - 1

ER -

The effect of beta-interferon therapy on myelin basic protein-elicited CD4+ T cell proliferation and cytokine production in multiple sclerosis

Abstract

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