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Region Hovedstaden - en del af Københavns Universitetshospital
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The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

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  • Christel M. Middeldorp
  • Janine F. Felix
  • Anubha Mahajan
  • Tarunveer S. Ahluwalia
  • Juha Auvinen
  • Meike Bartels
  • Jose Ramon Bilbao
  • Hans Bisgaard
  • Klaus Bønnelykke
  • Dorret I. Boomsma
  • Jonathan P. Bradfield
  • Mariona Bustamante
  • Zhanghua Chen
  • John A. Curtin
  • Adnan Custovic
  • George Davey Smith
  • Gareth E. Davies
  • Liesbeth Duijts
  • Peter R. Eastwood
  • Anders U. Eliasen
  • Xavier Estivill
  • David M. Evans
  • Iryna O. Fedko
  • W. James Gauderman
  • Frank Gilliland
  • Raquel Granell
  • Struan F.A. Grant
  • Monica Guxens
  • Hakon Hakonarson
  • Catharina A. Hartman
  • Joachim Heinrich
  • Anjali K. Henders
  • John Henderson
  • Patrick Holt
  • Jouke Jan Hottenga
  • Elina Hyppönen
  • Carmen Iñíguez
  • Bo Jacobsson
  • Vincent W.V. Jaddoe
  • Marjo Riitta Järvelin
  • Astanand Jugessur
  • Mika Kähönen
  • Jaakko Kaprio
  • Ville Karhunen
  • John P. Kemp
  • Gerard H. Koppelman
  • Ashish Kumar
  • Jari Lahti
  • Henrik Larsson
  • Debbie A. Lawlor
  • EArly Genetics Lifecourse Epidemiology (EAGLE) consortium
  • Early Growth Genetics (EGG) Consortium
Vis graf over relationer

The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as cardiovascular disease. Insight into the genetic etiology of childhood and adolescent traits and disorders may therefore provide new perspectives, not only on how to improve wellbeing during childhood, but also how to prevent later adverse outcomes. To achieve the sample sizes required for genetic research, the Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia were established. The majority of the participating cohorts are longitudinal population-based samples, but other cohorts with data on early childhood phenotypes are also involved. Cohorts often have a broad focus and collect(ed) data on various somatic and psychiatric traits as well as environmental factors. Genetic variants have been successfully identified for multiple traits, for example, birth weight, atopic dermatitis, childhood BMI, allergic sensitization, and pubertal growth. Furthermore, the results have shown that genetic factors also partly underlie the association with adult traits. As sample sizes are still increasing, it is expected that future analyses will identify additional variants. This, in combination with the development of innovative statistical methods, will provide detailed insight on the mechanisms underlying the transition from childhood to adult disorders. Both consortia welcome new collaborations. Policies and contact details are available from the corresponding authors of this manuscript and/or the consortium websites.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Epidemiology
Vol/bind34
Udgave nummer3
Sider (fra-til)279-300
Antal sider22
ISSN0393-2990
DOI
StatusUdgivet - 18 mar. 2019

ID: 58170153