The diagnostic value of immunohistochemically detected methylthioadenosine phosphorylase deficiency in malignant pleural mesotheliomas

Zarah Glad Zimling, Anne Jørgensen, Eric Santoni-Rugiu

20 Citationer (Scopus)

Abstract

  Malignant pleural mesothelioma (MPM) often causes diagnostic difficulties for pathologists. We assessed whether loss of methylthioadenosine phosphorylase (MTAP), a key enzyme in the intracellular recycling of adenosine triphosphate (ATP) often deleted in MPM, could be detected with immunohistochemistry (IHC) and used as a diagnostic marker for MPM.
OriginalsprogEngelsk
TidsskriftHistopathology
Vol/bind60
Udgave nummer6B
Sider (fra-til)E96-105
ISSN0309-0167
DOI
StatusUdgivet - 2012

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