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The development of AIDS or AIDS-related conditions in a cohort of HIV antibody-positive homosexual men during a 3-year follow-up period.

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Harvard

Pedersen, C, Kolby, P, Sindrup, J, Gaub, J, Ullman, S, Gerstoft, J, Lindhardt, BO & Dickmeiss, E 1989, 'The development of AIDS or AIDS-related conditions in a cohort of HIV antibody-positive homosexual men during a 3-year follow-up period.' Journal of Internal Medicine, bind 225, nr. 6, s. 403-409.

APA

Pedersen, C., Kolby, P., Sindrup, J., Gaub, J., Ullman, S., Gerstoft, J., ... Dickmeiss, E. (1989). The development of AIDS or AIDS-related conditions in a cohort of HIV antibody-positive homosexual men during a 3-year follow-up period. Journal of Internal Medicine, 225(6), 403-409.

CBE

Pedersen C, Kolby P, Sindrup J, Gaub J, Ullman S, Gerstoft J, Lindhardt BO, Dickmeiss E. 1989. The development of AIDS or AIDS-related conditions in a cohort of HIV antibody-positive homosexual men during a 3-year follow-up period. Journal of Internal Medicine. 225(6):403-409.

MLA

Vancouver

Author

Pedersen, C ; Kolby, P ; Sindrup, J ; Gaub, J ; Ullman, S ; Gerstoft, J ; Lindhardt, B O ; Dickmeiss, E. / The development of AIDS or AIDS-related conditions in a cohort of HIV antibody-positive homosexual men during a 3-year follow-up period. I: Journal of Internal Medicine. 1989 ; Bind 225, Nr. 6. s. 403-409.

Bibtex

@article{41925a4c6fce403aa78d82cc2cc8772e,
title = "The development of AIDS or AIDS-related conditions in a cohort of HIV antibody-positive homosexual men during a 3-year follow-up period.",
abstract = "One hundred and thirty-three homosexual men seropositive for the antibody against human immunodeficiency virus (HIV) were enrolled in a prospective study in 1984-85. The 3-year cumulative incidences of the acquired immunodeficiency syndrome (AIDS) and AIDS-related conditions, by life-table analyses, were 18{\%} and 34{\%}. The cumulative incidence of immune deficiency defined as CD4 lymphocytes less than 0.5 x 10(9) l-1 was 70{\%} at 3 years. Absence of antibodies to p24 antigen, HIV antigenaemia, CD4 lymphocytes less than 0.3 x 10 l-1 and elevated serum level of IgA were significantly associated with the development of AIDS. There was no association between disease progression and persistent generalized lymphadenopathy. When adjusted to the probable year of infection, these results are in accordance with previous cohort studies. It is concluded that most, or all, subjects seropositive for HIV will develop progressive loss of CD4 lymphocytes followed by clinical signs of immune deficiency, and that differences among previous cohorts with respect to disease progression are probably due to differences in the duration of infection.",
author = "C Pedersen and P Kolby and J Sindrup and J Gaub and S Ullman and J Gerstoft and Lindhardt, {B O} and E Dickmeiss",
year = "1989",
language = "English",
volume = "225",
pages = "403--409",
journal = "Journal of Internal Medicine",
issn = "0954-6820",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "6",

}

RIS

TY - JOUR

T1 - The development of AIDS or AIDS-related conditions in a cohort of HIV antibody-positive homosexual men during a 3-year follow-up period.

AU - Pedersen, C

AU - Kolby, P

AU - Sindrup, J

AU - Gaub, J

AU - Ullman, S

AU - Gerstoft, J

AU - Lindhardt, B O

AU - Dickmeiss, E

PY - 1989

Y1 - 1989

N2 - One hundred and thirty-three homosexual men seropositive for the antibody against human immunodeficiency virus (HIV) were enrolled in a prospective study in 1984-85. The 3-year cumulative incidences of the acquired immunodeficiency syndrome (AIDS) and AIDS-related conditions, by life-table analyses, were 18% and 34%. The cumulative incidence of immune deficiency defined as CD4 lymphocytes less than 0.5 x 10(9) l-1 was 70% at 3 years. Absence of antibodies to p24 antigen, HIV antigenaemia, CD4 lymphocytes less than 0.3 x 10 l-1 and elevated serum level of IgA were significantly associated with the development of AIDS. There was no association between disease progression and persistent generalized lymphadenopathy. When adjusted to the probable year of infection, these results are in accordance with previous cohort studies. It is concluded that most, or all, subjects seropositive for HIV will develop progressive loss of CD4 lymphocytes followed by clinical signs of immune deficiency, and that differences among previous cohorts with respect to disease progression are probably due to differences in the duration of infection.

AB - One hundred and thirty-three homosexual men seropositive for the antibody against human immunodeficiency virus (HIV) were enrolled in a prospective study in 1984-85. The 3-year cumulative incidences of the acquired immunodeficiency syndrome (AIDS) and AIDS-related conditions, by life-table analyses, were 18% and 34%. The cumulative incidence of immune deficiency defined as CD4 lymphocytes less than 0.5 x 10(9) l-1 was 70% at 3 years. Absence of antibodies to p24 antigen, HIV antigenaemia, CD4 lymphocytes less than 0.3 x 10 l-1 and elevated serum level of IgA were significantly associated with the development of AIDS. There was no association between disease progression and persistent generalized lymphadenopathy. When adjusted to the probable year of infection, these results are in accordance with previous cohort studies. It is concluded that most, or all, subjects seropositive for HIV will develop progressive loss of CD4 lymphocytes followed by clinical signs of immune deficiency, and that differences among previous cohorts with respect to disease progression are probably due to differences in the duration of infection.

M3 - Journal article

VL - 225

SP - 403

EP - 409

JO - Journal of Internal Medicine

JF - Journal of Internal Medicine

SN - 0954-6820

IS - 6

ER -

ID: 32500757