The CONNECT project: Combining macro- and micro-structure

Yaniv Assaf; Daniel C Alexander; Derek K Jones; Albero Bizzi; Tim Behrens; Chris A Clark; Yoram Cohen; Tim B Dyrby; Petra S Huppi; Thomas R Knoesche; Denis Lebihan; Geoff J M Parker; Cyril Poupon; Debbie Anaby; Alfred Anwander; Leah Bar; Daniel Barazany; Tamar Blumenfeld-Katzir; Silvia De-Santis; Delphine Duclap; Matteo Figini; Elda Fischi; Pamela Guevara; Penny Hubbard; Shir Hofstetter; Saad Jbabdi; Nicolas Kunz; Francois Lazeyras; Alice Lebois; Matthew G Liptrot; Henrik Lundell; Jean-François Mangin; David Moreno Dominguez; Darya Morozov; Jan Schreiber; Kiran Seunarine; Simone Nava; Cyril Poupon; Till Riffert; Efrat Sasson; Benoit Schmitt; Noam Shemesh; Stam N Sotiropoulos; Ido Tavor; Hui Gary Zhang; Feng-Lei Zhou; CONNECT consortium

doi:10.1016/j.neuroimage.2013.05.055

The CONNECT project: Combining macro- and micro-structure

Yaniv Assaf, Daniel C Alexander, Derek K Jones, Albero Bizzi, Tim Behrens, Chris A Clark, Yoram Cohen, Tim B Dyrby, Petra S Huppi, Thomas R Knoesche, Denis Lebihan, Geoff J M Parker, Cyril Poupon, Debbie Anaby, Alfred Anwander, Leah Bar, Daniel Barazany, Tamar Blumenfeld-Katzir, Silvia De-Santis, Delphine DuclapMatteo Figini, Elda Fischi, Pamela Guevara, Penny Hubbard, Shir Hofstetter, Saad Jbabdi, Nicolas Kunz, Francois Lazeyras, Alice Lebois, Matthew G Liptrot, Henrik Lundell, Jean-François Mangin, David Moreno Dominguez, Darya Morozov, Jan Schreiber, Kiran Seunarine, Simone Nava, Cyril Poupon, Till Riffert, Efrat Sasson, Benoit Schmitt, Noam Shemesh, Stam N Sotiropoulos, Ido Tavor, Hui Gary Zhang, Feng-Lei Zhou, CONNECT consortium

Funktions- og Billeddiagnostisk Enhed, MR-Forskningssektionen

111 Citationer (Scopus)

Abstract

In recent years, diffusion MRI has become an extremely important tool for studying the morphology of living brain tissue, as it provides unique insights into both its macrostructure and microstructure. Recent applications of diffusion MRI aimed to characterize the structural connectome using tractography to infer connectivity between brain regions. In parallel to the development of tractography, additional diffusion MRI based frameworks (CHARMED, AxCaliber, ActiveAx) were developed enabling the extraction of a multitude of micro-structural parameters (axon diameter distribution, mean axonal diameter and axonal density). This unique insight into both tissue microstructure and connectivity has enormous potential value in understanding the structure and organization of the brain as well as providing unique insights to abnormalities that underpin disease states. The CONNECT (Consortium Of Neuroimagers for the Non-invasive Exploration of brain Connectivity and Tracts) project aimed to combine tractography and micro-structural measures of the living human brain in order to obtain a better estimate of the connectome, while also striving to extend validation of these measurements. This paper summarizes the project and describes the perspective of using micro-structural measures to study the connectome.

Originalsprog	Engelsk
Tidsskrift	NeuroImage
Vol/bind	80
Sider (fra-til)	273-82
Antal sider	10
ISSN	1053-8119
DOI	https://doi.org/10.1016/j.neuroimage.2013.05.055
Status	Udgivet - 15 okt. 2013

Adgang til dokumentet

10.1016/j.neuroimage.2013.05.055

Citationsformater

Assaf, Y., Alexander, D. C., Jones, D. K., Bizzi, A., Behrens, T., Clark, C. A., Cohen, Y., Dyrby, T. B., Huppi, P. S., Knoesche, T. R., Lebihan, D., Parker, G. J. M., Poupon, C., Anaby, D., Anwander, A., Bar, L., Barazany, D., Blumenfeld-Katzir, T., De-Santis, S., ... CONNECT consortium (2013). The CONNECT project: Combining macro- and micro-structure. NeuroImage, 80, 273-82. https://doi.org/10.1016/j.neuroimage.2013.05.055

Assaf, Y, Alexander, DC, Jones, DK, Bizzi, A, Behrens, T, Clark, CA, Cohen, Y, Dyrby, TB, Huppi, PS, Knoesche, TR, Lebihan, D, Parker, GJM, Poupon, C, Anaby, D, Anwander, A, Bar, L, Barazany, D, Blumenfeld-Katzir, T, De-Santis, S, Duclap, D, Figini, M, Fischi, E, Guevara, P, Hubbard, P, Hofstetter, S, Jbabdi, S, Kunz, N, Lazeyras, F, Lebois, A, Liptrot, MG, Lundell, H, Mangin, J-F, Dominguez, DM, Morozov, D, Schreiber, J, Seunarine, K, Nava, S, Poupon, C, Riffert, T, Sasson, E, Schmitt, B, Shemesh, N, Sotiropoulos, SN, Tavor, I, Zhang, HG, Zhou, F-L & CONNECT consortium 2013, 'The CONNECT project: Combining macro- and micro-structure', NeuroImage, bind 80, s. 273-82. https://doi.org/10.1016/j.neuroimage.2013.05.055

@article{664b0d412132404daf51880007a78b46,

title = "The CONNECT project: Combining macro- and micro-structure",

abstract = "In recent years, diffusion MRI has become an extremely important tool for studying the morphology of living brain tissue, as it provides unique insights into both its macrostructure and microstructure. Recent applications of diffusion MRI aimed to characterize the structural connectome using tractography to infer connectivity between brain regions. In parallel to the development of tractography, additional diffusion MRI based frameworks (CHARMED, AxCaliber, ActiveAx) were developed enabling the extraction of a multitude of micro-structural parameters (axon diameter distribution, mean axonal diameter and axonal density). This unique insight into both tissue microstructure and connectivity has enormous potential value in understanding the structure and organization of the brain as well as providing unique insights to abnormalities that underpin disease states. The CONNECT (Consortium Of Neuroimagers for the Non-invasive Exploration of brain Connectivity and Tracts) project aimed to combine tractography and micro-structural measures of the living human brain in order to obtain a better estimate of the connectome, while also striving to extend validation of these measurements. This paper summarizes the project and describes the perspective of using micro-structural measures to study the connectome.",

author = "Yaniv Assaf and Alexander, {Daniel C} and Jones, {Derek K} and Albero Bizzi and Tim Behrens and Clark, {Chris A} and Yoram Cohen and Dyrby, {Tim B} and Huppi, {Petra S} and Knoesche, {Thomas R} and Denis Lebihan and Parker, {Geoff J M} and Cyril Poupon and Debbie Anaby and Alfred Anwander and Leah Bar and Daniel Barazany and Tamar Blumenfeld-Katzir and Silvia De-Santis and Delphine Duclap and Matteo Figini and Elda Fischi and Pamela Guevara and Penny Hubbard and Shir Hofstetter and Saad Jbabdi and Nicolas Kunz and Francois Lazeyras and Alice Lebois and Liptrot, {Matthew G} and Henrik Lundell and Jean-Fran{\c c}ois Mangin and Dominguez, {David Moreno} and Darya Morozov and Jan Schreiber and Kiran Seunarine and Simone Nava and Cyril Poupon and Till Riffert and Efrat Sasson and Benoit Schmitt and Noam Shemesh and Sotiropoulos, {Stam N} and Ido Tavor and Zhang, {Hui Gary} and Feng-Lei Zhou and {CONNECT consortium}",

year = "2013",

month = oct,

day = "15",

doi = "10.1016/j.neuroimage.2013.05.055",

language = "English",

volume = "80",

pages = "273--82",

journal = "NeuroImage",

issn = "1053-8119",

publisher = "Academic Press",

}

TY - JOUR

T1 - The CONNECT project

T2 - Combining macro- and micro-structure

AU - Assaf, Yaniv

AU - Alexander, Daniel C

AU - Jones, Derek K

AU - Bizzi, Albero

AU - Behrens, Tim

AU - Clark, Chris A

AU - Cohen, Yoram

AU - Dyrby, Tim B

AU - Huppi, Petra S

AU - Knoesche, Thomas R

AU - Lebihan, Denis

AU - Parker, Geoff J M

AU - Poupon, Cyril

AU - Anaby, Debbie

AU - Anwander, Alfred

AU - Bar, Leah

AU - Barazany, Daniel

AU - Blumenfeld-Katzir, Tamar

AU - De-Santis, Silvia

AU - Duclap, Delphine

AU - Figini, Matteo

AU - Fischi, Elda

AU - Guevara, Pamela

AU - Hubbard, Penny

AU - Hofstetter, Shir

AU - Jbabdi, Saad

AU - Kunz, Nicolas

AU - Lazeyras, Francois

AU - Lebois, Alice

AU - Liptrot, Matthew G

AU - Lundell, Henrik

AU - Mangin, Jean-François

AU - Dominguez, David Moreno

AU - Morozov, Darya

AU - Schreiber, Jan

AU - Seunarine, Kiran

AU - Nava, Simone

AU - Poupon, Cyril

AU - Riffert, Till

AU - Sasson, Efrat

AU - Schmitt, Benoit

AU - Shemesh, Noam

AU - Sotiropoulos, Stam N

AU - Tavor, Ido

AU - Zhang, Hui Gary

AU - Zhou, Feng-Lei

AU - CONNECT consortium

PY - 2013/10/15

Y1 - 2013/10/15

N2 - In recent years, diffusion MRI has become an extremely important tool for studying the morphology of living brain tissue, as it provides unique insights into both its macrostructure and microstructure. Recent applications of diffusion MRI aimed to characterize the structural connectome using tractography to infer connectivity between brain regions. In parallel to the development of tractography, additional diffusion MRI based frameworks (CHARMED, AxCaliber, ActiveAx) were developed enabling the extraction of a multitude of micro-structural parameters (axon diameter distribution, mean axonal diameter and axonal density). This unique insight into both tissue microstructure and connectivity has enormous potential value in understanding the structure and organization of the brain as well as providing unique insights to abnormalities that underpin disease states. The CONNECT (Consortium Of Neuroimagers for the Non-invasive Exploration of brain Connectivity and Tracts) project aimed to combine tractography and micro-structural measures of the living human brain in order to obtain a better estimate of the connectome, while also striving to extend validation of these measurements. This paper summarizes the project and describes the perspective of using micro-structural measures to study the connectome.

AB - In recent years, diffusion MRI has become an extremely important tool for studying the morphology of living brain tissue, as it provides unique insights into both its macrostructure and microstructure. Recent applications of diffusion MRI aimed to characterize the structural connectome using tractography to infer connectivity between brain regions. In parallel to the development of tractography, additional diffusion MRI based frameworks (CHARMED, AxCaliber, ActiveAx) were developed enabling the extraction of a multitude of micro-structural parameters (axon diameter distribution, mean axonal diameter and axonal density). This unique insight into both tissue microstructure and connectivity has enormous potential value in understanding the structure and organization of the brain as well as providing unique insights to abnormalities that underpin disease states. The CONNECT (Consortium Of Neuroimagers for the Non-invasive Exploration of brain Connectivity and Tracts) project aimed to combine tractography and micro-structural measures of the living human brain in order to obtain a better estimate of the connectome, while also striving to extend validation of these measurements. This paper summarizes the project and describes the perspective of using micro-structural measures to study the connectome.

U2 - 10.1016/j.neuroimage.2013.05.055

DO - 10.1016/j.neuroimage.2013.05.055

M3 - Journal article

C2 - 23727318

SN - 1053-8119

VL - 80

SP - 273

EP - 282

JO - NeuroImage

JF - NeuroImage

ER -

The CONNECT project: Combining macro- and micro-structure

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater