Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

The concentration of the cleaved suPAR forms in pre- and postoperative plasma samples improves the prediction of survival in colorectal cancer: A nationwide multicenter validation and discovery study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Long-term follow-up of RET Y791F carriers in Denmark 1994-2017: A National Cohort Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Prognostic value of biochemical variables for survival after surgery for metastatic bone disease of the extremities

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Importance of margin width in breast-conserving treatment of early breast cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Improved survival with early adjuvant chemotherapy after colonic resection for stage III colonic cancer: A nationwide study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. The Incidence of Free Peritoneal Tumor Cells before and after Neoadjuvant Chemotherapy in Gastroesophageal Junction Cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Laparoscopy to Assist Surgical Decisions Related to Necrotizing Enterocolitis in Preterm Neonates

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Prognostic factors for relapse in patients with clinical stage I testicular cancer: Protocol for a Danish nationwide cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Gel-Based Proteomics of Clinical Samples Identifies Potential Serological Biomarkers for Early Detection of Colorectal Cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Optimized Biobanking Procedures for Preservation of RNA in Tissue: Comparison of Snap-Freezing and RNAlater-Fixation Methods

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Background and Objectives: The aim was to evaluate the prognostic biomarker potential of the soluble urokinase-type plasminogen activator receptor (suPAR) in plasma samples collected pre- and postoperatively from patients resected for colorectal cancer (CRC). Methods: Patients with CRC were recruited prospectively at six centers from 2006 to 2008. Preoperative plasma samples were available from 494 patients and from 328 of these patients at 6 months postoperatively. Determinations of intact soluble uPAR (suPAR) suPAR(I-III) and the cleaved forms suPAR(I-III) + (II-III) and uPAR(I) were performed. Clinical data were retrieved retrospectively. Results: In a multivariable model based on preoperative plasma samples suPAR(I-III) + (II-III) and uPAR(I) showed an independent statistically significant association to long term survival. When including the change in biomarker level between the pre- and postoperatively samples the hazard ratios were 3.06 (95% confidence interval [CI], 1.78-5.28; P <.0001) and 2.24 (95% CI, 1.59-3.16; P <.0001) for suPAR(I-III) + (II-III) and uPAR(I), respectively. A one-unit decrease in biomarker levels between the pre- and postoperative levels resulted in a 55% and 34% reduction in the risk estimate of death for suPAR(I-III) + (II-III) and uPAR(I), respectively. Conclusion: This study validates previously findings regarding the prognostic significance of suPAR in preoperative samples. The inclusion of postoperative samples added further prognostic information.

OriginalsprogEngelsk
TidsskriftJournal of Surgical Oncology
Vol/bind120
Udgave nummer8
Sider (fra-til)1404-1411
Antal sider8
ISSN0022-4790
DOI
StatusUdgivet - dec. 2019

Bibliografisk note

© 2019 Wiley Periodicals, Inc.

ID: 58214430