The common D302H variant of CASP8 is associated with risk of glioma

Lara Bethke; Kate Sullivan; Emily Webb; Anne Murray; Minouk Schoemaker; Anssi Auvinen; Anne Kiuru; Tiina Salminen; Christoffer Johansen; Helle Collatz Christensen; Kenneth Muir; Patricia McKinney; Sarah Hepworth; Polyxeni Dimitropoulou; Artitaya Lophatananon; Maria Feychting; Stefan Lönn; Anders Ahlbom; Beatrice Malmer; Roger Henriksson; Anthony Swerdlow; Richard Houlston

doi:10.1158/1055-9965.EPI-07-2807

The common D302H variant of CASP8 is associated with risk of glioma

Lara Bethke, Kate Sullivan, Emily Webb, Anne Murray, Minouk Schoemaker, Anssi Auvinen, Anne Kiuru, Tiina Salminen, Christoffer Johansen, Helle Collatz Christensen, Kenneth Muir, Patricia McKinney, Sarah Hepworth, Polyxeni Dimitropoulou, Artitaya Lophatananon, Maria Feychting, Stefan Lönn, Anders Ahlbom, Beatrice Malmer, Roger HenrikssonAnthony Swerdlow, Richard Houlston

46 Citationer (Scopus)

Abstract

Caspase 8 (CASP8) is a key regulator of apoptosis or programmed cell death, and, hence, a defense against cancer. We tested the hypothesis that the CASP8 polymorphism D302H influences risk of glioma through analysis of five series of glioma case patients and controls (n = 1,005 and 1,011, respectively). Carrier status for the rare allele of D302H was associated with a 1.37-fold increased risk (95% confidence interval, 1.10-1.70; P = 0.004). The association of CASP8 D302H with glioma risk indicates the importance of inherited variation in the apoptosis pathway in susceptibility to this form of primary brain tumor.

Originalsprog	Engelsk
Tidsskrift	Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Vol/bind	17
Udgave nummer	4
Sider (fra-til)	987-9
Antal sider	3
ISSN	1055-9965
DOI	https://doi.org/10.1158/1055-9965.EPI-07-2807
Status	Udgivet - apr. 2008
Udgivet eksternt	Ja

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10.1158/1055-9965.EPI-07-2807

Citationsformater

Bethke, L., Sullivan, K., Webb, E., Murray, A., Schoemaker, M., Auvinen, A., Kiuru, A., Salminen, T., Johansen, C., Christensen, H. C., Muir, K., McKinney, P., Hepworth, S., Dimitropoulou, P., Lophatananon, A., Feychting, M., Lönn, S., Ahlbom, A., Malmer, B., ... Houlston, R. (2008). The common D302H variant of CASP8 is associated with risk of glioma. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 17(4), 987-9. https://doi.org/10.1158/1055-9965.EPI-07-2807

The common D302H variant of CASP8 is associated with risk of glioma. / Bethke, Lara; Sullivan, Kate; Webb, Emily et al.
I: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Bind 17, Nr. 4, 04.2008, s. 987-9.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Bethke, L, Sullivan, K, Webb, E, Murray, A, Schoemaker, M, Auvinen, A, Kiuru, A, Salminen, T, Johansen, C, Christensen, HC, Muir, K, McKinney, P, Hepworth, S, Dimitropoulou, P, Lophatananon, A, Feychting, M, Lönn, S, Ahlbom, A, Malmer, B, Henriksson, R, Swerdlow, A & Houlston, R 2008, 'The common D302H variant of CASP8 is associated with risk of glioma', Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, bind 17, nr. 4, s. 987-9. https://doi.org/10.1158/1055-9965.EPI-07-2807

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abstract = "Caspase 8 (CASP8) is a key regulator of apoptosis or programmed cell death, and, hence, a defense against cancer. We tested the hypothesis that the CASP8 polymorphism D302H influences risk of glioma through analysis of five series of glioma case patients and controls (n = 1,005 and 1,011, respectively). Carrier status for the rare allele of D302H was associated with a 1.37-fold increased risk (95% confidence interval, 1.10-1.70; P = 0.004). The association of CASP8 D302H with glioma risk indicates the importance of inherited variation in the apoptosis pathway in susceptibility to this form of primary brain tumor.",

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AU - Auvinen, Anssi

AU - Kiuru, Anne

AU - Salminen, Tiina

AU - Johansen, Christoffer

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AU - McKinney, Patricia

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AU - Feychting, Maria

AU - Lönn, Stefan

AU - Ahlbom, Anders

AU - Malmer, Beatrice

AU - Henriksson, Roger

AU - Swerdlow, Anthony

AU - Houlston, Richard

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AB - Caspase 8 (CASP8) is a key regulator of apoptosis or programmed cell death, and, hence, a defense against cancer. We tested the hypothesis that the CASP8 polymorphism D302H influences risk of glioma through analysis of five series of glioma case patients and controls (n = 1,005 and 1,011, respectively). Carrier status for the rare allele of D302H was associated with a 1.37-fold increased risk (95% confidence interval, 1.10-1.70; P = 0.004). The association of CASP8 D302H with glioma risk indicates the importance of inherited variation in the apoptosis pathway in susceptibility to this form of primary brain tumor.

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KW - Male

KW - Middle Aged

KW - Multicenter Studies as Topic

KW - Polymorphism, Genetic

KW - Polymorphism, Single Nucleotide

KW - Risk Factors

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DO - 10.1158/1055-9965.EPI-07-2807

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JO - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

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The common D302H variant of CASP8 is associated with risk of glioma

Abstract

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