TY - JOUR
T1 - The cognitive effects of opioids in cancer
T2 - a systematic review
AU - Kurita, Geana Paula
AU - Lundorff, Lena
AU - Pimenta, Cibele Andrucioli de Mattos
AU - Sjøgren, Per
PY - 2009/1
Y1 - 2009/1
N2 - OBJECTIVE AND METHODS: In order to better understand the effects of opioids on the cognitive function in cancer pain patients, a literature search was performed in PubMed, EMBASE, PsycInfo, CINAHL and Lilacs databases. Ten controlled trials were selected and classified according to the study design, the level of evidence, and opioid regimen.RESULT: Six studies reported association between poor cognitive performance (reaction time, attention, balance, and memory) and opioid use.CONCLUSION: These cognitive deficits were captured with neuropsychological tests; however, their clinical relevance is still uncertain.
AB - OBJECTIVE AND METHODS: In order to better understand the effects of opioids on the cognitive function in cancer pain patients, a literature search was performed in PubMed, EMBASE, PsycInfo, CINAHL and Lilacs databases. Ten controlled trials were selected and classified according to the study design, the level of evidence, and opioid regimen.RESULT: Six studies reported association between poor cognitive performance (reaction time, attention, balance, and memory) and opioid use.CONCLUSION: These cognitive deficits were captured with neuropsychological tests; however, their clinical relevance is still uncertain.
KW - Analgesics, Opioid/adverse effects
KW - Attention/drug effects
KW - Cognition/drug effects
KW - Controlled Clinical Trials as Topic
KW - Humans
KW - Memory/drug effects
KW - Neoplasms/complications
KW - Neuropsychological Tests
KW - Pain/drug therapy
KW - Reaction Time/drug effects
U2 - 10.1007/s00520-008-0497-y
DO - 10.1007/s00520-008-0497-y
M3 - Review
C2 - 18762994
SN - 0941-4355
VL - 17
SP - 11
EP - 21
JO - Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
JF - Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
IS - 1
ER -