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The Clinical Relevance of Natural Rubber Latex-Specific IgE in Patients Sensitized to Timothy Grass Pollen

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  1. The SQ House Dust Mite SLIT-Tablet Is Well Tolerated in Patients with House Dust Mite Respiratory Allergic Disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. How Not to Be Misled by Disorders Mimicking Angioedema: A Review of Pseudoangioedema

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  3. Insect Sting Reactions and Specific IgE to Venom and Major Allergens in a General Population

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. The Unsolved Relationship of Alcohol and Asthma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

  5. Development of a Hypoallergenic Recombinant Parvalbumin for First-in-Man Subcutaneous Immunotherapy of Fish Allergy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Allergy Development in Adulthood: An Occupational Cohort Study of the Manufacturing of Industrial Enzymes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Perioperative anaphylaxis in children: Etiology, time sequence, and patterns of clinical reactivity

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Identifying and managing patients at risk of severe allergic reactions to food: Report from two iFAAM workshops

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. An EAACI position paper on the investigation of perioperative immediate hypersensitivity reactions

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: In pollen-allergic patients, cross-reacting allergens including cross-reactive carbohydrate determinants (CCDs) and profilins may result in positive natural rubber latex (NRL)-specific IgE (sIgE) antibody tests but the relationship between this sensitization and clinical NRL type 1 allergy is poorly described.

OBJECTIVE: The aims of this study were to determine the frequency and clinical relevance of NRL sIgE in grass pollen-sensitized individuals and to investigate which NRL allergen components these individuals were sensitized to.

METHODS: A total of 383 grass-sensitized patients answered questions about NRL allergy symptoms and their stored sera from previous investigations were analyzed for NRL sIgE. Patients with NRL sIgE (n = 32) underwent further investigations comprising medical history, skin prick test with NRL and inhalational allergens, and an additional blood sample. The additional blood samples were analyzed for total IgE and sIgE against NRL, timothy grass, birch, rHev b 1, 3, 5, 6.01, 6.02, 8, 9, 11, rPhl p 12, and MUXF3, which was used as a marker of CCD sensitization.

RESULTS: Overall, 9.4% of all grass pollen-sensitized individuals showed IgE sensitization to NRL but only 1.6% had a confirmed type I NRL allergy. CCD and Hev b 8 explained the clinically irrelevant NRL IgE sensitization in 65% of the cases. We found a highly significant correlation between NRL profilin (Hev b 8) sensitization and grass profilin (Phl p 12) sensitization (p < 0.0001).

CONCLUSIONS: Data from this study support the hypothesis that in patients with grass pollen sensitization, Hev b 8 mono-sensitization has little or no clinical relevance and is caused by cross sensitization from grass profilin (Phl p 12).

OriginalsprogEngelsk
TidsskriftInternational Archives of Allergy and Immunology
Vol/bind178
Udgave nummer4
Sider (fra-til)345-354
Antal sider10
ISSN1018-2438
DOI
StatusUdgivet - 11 mar. 2019

Bibliografisk note

© 2019 S. Karger AG, Basel.

ID: 58996307