Abstract
BACKGROUND: The aim of this study was to determine whether there is a protective effect of combination antiretroviral therapy (cART) on the development of clinical events in patients with ongoing severe immunosuppression. METHODS: A total of 3,780 patients from the EuroSIDA study under follow-up after 2001 with a current CD4(+) T-cell count ≤200 cells/mm(3) were stratified into five groups: group 1, viral load (VL)100,000 copies/ml (IRR 0.66; 95% CI 0.44-1.00). Similar relationships were seen for non-AIDS events and AIDS events when considered separately. CONCLUSIONS: In patients with ongoing severe immunosuppression, cART was associated with significant clinical benefits in patients with suboptimal virological control or virological failure.
Originalsprog | Engelsk |
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Tidsskrift | Antiviral Therapy |
Vol/bind | 17 |
Udgave nummer | 7 |
Sider (fra-til) | 1291-1300 |
ISSN | 1359-6535 |
DOI | |
Status | Udgivet - 2012 |