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Udgivet

The CHANGE trial: no superiority of lifestyle coaching plus care coordination plus treatment as usual compared to treatment as usual alone in reducing risk of cardiovascular disease in adults with schizophrenia spectrum disorders and abdominal obesity

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. CHANGE – det gælder livet

    Projekt: Typer af projekter

  1. Effectiveness of cognitive remediation in the ultra-high risk state for psychosis

    Publikation: Bidrag til tidsskriftLetterForskningpeer review

  2. Mental illness among relatives of successful academics: implications for psychopathology-creativity research

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Transdiagnostic psychiatry: a systematic review

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Borderline personality disorder or a disorder within the schizophrenia spectrum? A psychopathological study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Testing a neurophenomenological model of basic self disturbance in early psychosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Life expectancy in patients with schizophrenia is reduced by 20 years for men and 15 years for women compared to the general population. About 60% of the excess mortality is due to physical illnesses, with cardiovascular disease being dominant. CHANGE was a randomized, parallel-group, superiority, multi-centre trial with blinded outcome assessment, testing the efficacy of an intervention aimed to improve cardiovascular risk profile and hereby potentially reduce mortality. A total of 428 patients with schizophrenia spectrum disorders and abdominal obesity were recruited and centrally randomized 1:1:1 to 12 months of lifestyle coaching plus care coordination plus treatment as usual (N=138), or care coordination plus treatment as usual (N=142), or treatment as usual alone (N=148). The primary outcome was 10-year risk of cardiovascular disease assessed post-treatment and standardized to age 60. At follow-up, the mean 10-year risk of cardiovascular disease was 8.4 ± 6.7% in the group receiving lifestyle coaching, 8.5 ± 7.5% in the care coordination group, and 8.0 ± 6.5% in the treatment as usual group (p=0.41). We found no intervention effects for any secondary or exploratory outcomes, including cardiorespiratory fitness, physical activity, weight, diet and smoking. In conclusion, the CHANGE trial did not support superiority of individual lifestyle coaching or care coordination compared to treatment as usual in reducing cardiovascular risk in patients with schizophrenia spectrum disorders and abdominal obesity.

OriginalsprogEngelsk
TidsskriftWorld Psychiatry
Vol/bind15
Udgave nummer2
Sider (fra-til)155-65
Antal sider11
ISSN1723-8617
DOI
StatusUdgivet - jun. 2016

ID: 46495806