Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

The cGMP-Degrading Enzyme Phosphodiesterase-5 (PDE5) in Cerebral Small Arteries of Older People

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Vacuoles, Often Containing Glycogen, Are a Consistent Finding in Hypokalemic Periodic Paralysis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Molecular Characterization of the Danish Prion Diseases Cohort With Special Emphasis on Rare and Unique Cases

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. A Novel Eight Octapeptide Repeat Insertion in PRNP Causing Prion Disease in a Danish Family

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Differential Muscle Involvement in Mice and Humans Affected by McArdle Disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Time trends in incidence, comorbidity, and mortality of ischemic stroke in Denmark, 1996-2016

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Atypisk aura forårsaget af blodprop hos en 42-årig mand med migræne med aura.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. How to identify fatigue in stroke patients: an investigation of the post-stroke fatigue case definition validity

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Første tilfælde af Mycobacterium chimaerainfektion relateret til åben thoraxkirurgi i Danmark

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Cerebral small vessel disease in deep penetrating arteries is a major cause of lacunar infarcts, white matter lesions and vascular cognitive impairment. Local cerebral blood flow in these small vessels is controlled by endothelial-derived nitric oxide, which exerts a primary vasodilator stimulus on vascular myocytes, via cytoplasmic cyclic GMP. Here, we investigated whether the cGMP-degrading enzyme phosphodiesterase-5 (PDE5) is present in small penetrating arteries in the deep subcortical white matter of older people. Frontal cortical tissue blocks were examined from donated brains of older people (n = 42, 24 male: 18 female, median age 81, range: 59-100 years). PDE5, detected by immunohistochemical labeling, was graded as absent, sparse, or abundant in vascular cells within small arteries in subcortical white matter (vessel outer diameter: 20-100 µm). PDE5 labeling within arterial myocytes was detected in all cases. Degree of PDE5 expression (absent, sparse, or abundant) was not associated with age or with neuropathological diagnosis of small vessel disease. In conclusion, PDE5 is present in vascular myocytes within small penetrating arteries in older people. This is a potential molecular target for pharmacological interventions.

OriginalsprogEngelsk
TidsskriftJournal of Neuropathology and Experimental Neurology
Vol/bind78
Udgave nummer2
Sider (fra-til)191-194
Antal sider4
ISSN0002-9564
DOI
StatusUdgivet - 1 feb. 2019

ID: 59116042