The cerebrospinal fluid levels of tau, growth-associated protein-43 and soluble amyloid precursor protein correlate in Alzheimer's disease, reflecting a common pathophysiological process

M Sjögren, P Davidsson, J Gottfries, H Vanderstichele, A Edman, E Vanmechelen, A Wallin, K Blennow

97 Citationer (Scopus)

Abstract

Cerebrospinal fluid (CSF) levels of tau (total tau), growth-associated protein-43 (GAP-43), soluble amyloid precursor protein (sAPP; i.e. total sAPP), and beta-amyloid(42) (Abeta(42)) were studied in patients with frontotemporal dementia (FTD; n = 14), Alzheimer's disease (AD; n = 47) and vascular dementia (VAD; n = 16), and in age-matched controls (n = 12). CSF-tau was increased in AD compared to controls and FTD (p < 0.001 for both). CSF-GAP-43 was increased in AD compared to controls (p < 0.05), and both CSF-GAP-43 and CSF-sAPP were increased in AD compared to FTD (p < 0.01). Positive and highly significant correlations were found between CSF-tau and CSF-GAP-43 in all groups and between CSF-tau, CSF-GAP-43 and CSF-sAPP in AD. The correlations found may reflect a common pathophysiologic process such as axonal degeneration.

OriginalsprogEngelsk
TidsskriftDementia and Geriatric Cognitive Disorders
Vol/bind12
Udgave nummer4
Sider (fra-til)257-64
Antal sider8
ISSN1420-8008
StatusUdgivet - 15 maj 2001
Udgivet eksterntJa

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