TY - JOUR
T1 - The bronchial response to mannitol is attenuated by a previous methacholine test
T2 - but not vice versa
AU - Gade, E
AU - Thomsen, S F
AU - Porsbjerg, C
AU - Backer, V
PY - 2009/7
Y1 - 2009/7
N2 - AIM: To examine the airway response to inhaled mannitol performed before or after a methacholine challenge test in a group of asthmatics with different levels of disease.METHODS: A total of 48 asthmatics, 18-73 years of age, were included in the study. Two pairs of challenges were performed in a random order on two separate days > or =24 h apart: either with mannitol performed first on day one, followed > or =1 h by methacholine, and methacholine as the first on day two, followed > or =1 h by mannitol or vice versa. A questionnaire-based interview was performed and lung function, exhaled nitric oxide, skin prick test, and blood eosinophil count were measured.RESULTS: A total of 44% of the asthmatics used inhaled corticosteroids and 48% were atopic. The airway response to mannitol was attenuated when mannitol was given after methacholine, compared with the response to mannitol when it was given first [log response dose ratio (RDR): 1.42 vs. 1.60 (P=0.004)], whereas the response to methacholine was unchanged in the opposite test order [log RDR: 0.81 vs. 0.96 (P=0.102)].CONCLUSION: Bronchial challenges with inhaled mannitol and methacholine may be performed on the same day but provocation with mannitol should be performed before methacholine.
AB - AIM: To examine the airway response to inhaled mannitol performed before or after a methacholine challenge test in a group of asthmatics with different levels of disease.METHODS: A total of 48 asthmatics, 18-73 years of age, were included in the study. Two pairs of challenges were performed in a random order on two separate days > or =24 h apart: either with mannitol performed first on day one, followed > or =1 h by methacholine, and methacholine as the first on day two, followed > or =1 h by mannitol or vice versa. A questionnaire-based interview was performed and lung function, exhaled nitric oxide, skin prick test, and blood eosinophil count were measured.RESULTS: A total of 44% of the asthmatics used inhaled corticosteroids and 48% were atopic. The airway response to mannitol was attenuated when mannitol was given after methacholine, compared with the response to mannitol when it was given first [log response dose ratio (RDR): 1.42 vs. 1.60 (P=0.004)], whereas the response to methacholine was unchanged in the opposite test order [log RDR: 0.81 vs. 0.96 (P=0.102)].CONCLUSION: Bronchial challenges with inhaled mannitol and methacholine may be performed on the same day but provocation with mannitol should be performed before methacholine.
KW - Administration, Inhalation
KW - Adolescent
KW - Adult
KW - Aged
KW - Asthma/diagnosis
KW - Bronchi/drug effects
KW - Bronchial Hyperreactivity/diagnosis
KW - Bronchial Provocation Tests/methods
KW - Dose-Response Relationship, Drug
KW - Female
KW - Humans
KW - Interviews as Topic
KW - Male
KW - Mannitol/administration & dosage
KW - Methacholine Chloride/immunology
KW - Middle Aged
KW - Surveys and Questionnaires
KW - Young Adult
U2 - 10.1111/j.1365-2222.2009.03274.x
DO - 10.1111/j.1365-2222.2009.03274.x
M3 - Journal article
C2 - 19489848
SN - 0954-7894
VL - 39
SP - 966
EP - 971
JO - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
IS - 7
ER -