The broad-spectrum cation channel blocker pinokalant (LOE 908 MS) reduces brain infarct volume in rats: a temperature-controlled histological study

Keyphrases

• Cation Channel 100%
• Channel Blocker 100%
• Transient Middle Cerebral Artery Occlusion (tMCAO) 100%
• Histological Study 100%
• Temperature Control 100%
• Brain Infarct Volume 100%
• Infarct Volume 75%
• Mean Arterial Pressure 50%
• Loading Dose 50%
• Body Temperature 50%
• Plasma Concentration 25%
• Beneficial Effects 25%
• Treatment Group 25%
• Metabolic 25%
• Acute Phase 25%
• Ca2+ 25%
• Wistar Rats 25%
• Na + 25%
• Electrophysiologic 25%
• Cardiac Magnetic Resonance Imaging (cMRI) 25%
• Infarction 25%
• Infarct Size 25%
• Effective Compounds 25%
• Neuroprotection 25%
• Phase Following 25%
• Plasma Drug Concentration 25%
• Brain Section 25%
• Broad-spectrum Inhibitor 25%
• Lesion Size 25%
• Ischemic Penumbra 25%
• Focal Cerebral Ischemia 25%
• Halothane 25%
• Telemetry 25%
• Microinfarcts 25%

Neuroscience

• Cation Channel 100%
• Middle Cerebral Artery 100%
• Channel Blocker 100%
• Blood Plasma 50%
• Magnetic Resonance Imaging 25%
• Brain Ischemia 25%
• Neuroprotection 25%
• Halothane 25%