The blood-brain barrier is intact after levodopa-induced dyskinesias in parkinsonian primates--evidence from in vivo neuroimaging studies

Arnar Astradsson; Bruce G Jenkins; Ji-Kyung Choi; Penelope J Hallett; Michele A Levesque; Jack S McDowell; Anna-Liisa Brownell; Roger D Spealman; Ole Isacson

doi:10.1016/j.nbd.2009.05.018

The blood-brain barrier is intact after levodopa-induced dyskinesias in parkinsonian primates--evidence from in vivo neuroimaging studies

Arnar Astradsson, Bruce G Jenkins, Ji-Kyung Choi, Penelope J Hallett, Michele A Levesque, Jack S McDowell, Anna-Liisa Brownell, Roger D Spealman, Ole Isacson

29 Citationer (Scopus)

Abstract

It has been suggested, based on rodent studies, that levodopa (L-dopa) induced dyskinesia is associated with a disrupted blood-brain barrier (BBB). We have investigated BBB integrity with in vivo neuroimaging techniques in six 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) lesioned primates exhibiting L-dopa-induced dyskinesia. Magnetic resonance imaging (MRI) performed before and after injection of Gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) revealed an intact BBB in the basal ganglia showing that l-dopa-induced dyskinesia is not associated with a disrupted BBB in this model.

Originalsprog	Engelsk
Tidsskrift	Neurobiology of Disease
Vol/bind	35
Udgave nummer	3
Sider (fra-til)	348-51
Antal sider	4
ISSN	0969-9961
DOI	https://doi.org/10.1016/j.nbd.2009.05.018
Status	Udgivet - sep. 2009

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10.1016/j.nbd.2009.05.018

Citationsformater

Astradsson, A., Jenkins, B. G., Choi, J.-K., Hallett, P. J., Levesque, M. A., McDowell, J. S., Brownell, A.-L., Spealman, R. D., & Isacson, O. (2009). The blood-brain barrier is intact after levodopa-induced dyskinesias in parkinsonian primates--evidence from in vivo neuroimaging studies. Neurobiology of Disease, 35(3), 348-51. https://doi.org/10.1016/j.nbd.2009.05.018

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title = "The blood-brain barrier is intact after levodopa-induced dyskinesias in parkinsonian primates--evidence from in vivo neuroimaging studies",

abstract = "It has been suggested, based on rodent studies, that levodopa (L-dopa) induced dyskinesia is associated with a disrupted blood-brain barrier (BBB). We have investigated BBB integrity with in vivo neuroimaging techniques in six 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) lesioned primates exhibiting L-dopa-induced dyskinesia. Magnetic resonance imaging (MRI) performed before and after injection of Gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) revealed an intact BBB in the basal ganglia showing that l-dopa-induced dyskinesia is not associated with a disrupted BBB in this model.",

keywords = "1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Animals, Antiparkinson Agents, Blood-Brain Barrier, Brain, Dyskinesia, Drug-Induced, Gadolinium DTPA, Levodopa, Macaca fascicularis, Magnetic Resonance Imaging, Male, Parkinsonian Disorders, Time Factors",

author = "Arnar Astradsson and Jenkins, {Bruce G} and Ji-Kyung Choi and Hallett, {Penelope J} and Levesque, {Michele A} and McDowell, {Jack S} and Anna-Liisa Brownell and Spealman, {Roger D} and Ole Isacson",

year = "2009",

month = sep,

doi = "10.1016/j.nbd.2009.05.018",

language = "English",

volume = "35",

pages = "348--51",

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issn = "0969-9961",

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TY - JOUR

T1 - The blood-brain barrier is intact after levodopa-induced dyskinesias in parkinsonian primates--evidence from in vivo neuroimaging studies

AU - Astradsson, Arnar

AU - Jenkins, Bruce G

AU - Choi, Ji-Kyung

AU - Hallett, Penelope J

AU - Levesque, Michele A

AU - McDowell, Jack S

AU - Brownell, Anna-Liisa

AU - Spealman, Roger D

AU - Isacson, Ole

PY - 2009/9

Y1 - 2009/9

N2 - It has been suggested, based on rodent studies, that levodopa (L-dopa) induced dyskinesia is associated with a disrupted blood-brain barrier (BBB). We have investigated BBB integrity with in vivo neuroimaging techniques in six 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) lesioned primates exhibiting L-dopa-induced dyskinesia. Magnetic resonance imaging (MRI) performed before and after injection of Gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) revealed an intact BBB in the basal ganglia showing that l-dopa-induced dyskinesia is not associated with a disrupted BBB in this model.

AB - It has been suggested, based on rodent studies, that levodopa (L-dopa) induced dyskinesia is associated with a disrupted blood-brain barrier (BBB). We have investigated BBB integrity with in vivo neuroimaging techniques in six 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) lesioned primates exhibiting L-dopa-induced dyskinesia. Magnetic resonance imaging (MRI) performed before and after injection of Gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) revealed an intact BBB in the basal ganglia showing that l-dopa-induced dyskinesia is not associated with a disrupted BBB in this model.

KW - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

KW - Animals

KW - Antiparkinson Agents

KW - Blood-Brain Barrier

KW - Brain

KW - Dyskinesia, Drug-Induced

KW - Gadolinium DTPA

KW - Levodopa

KW - Macaca fascicularis

KW - Magnetic Resonance Imaging

KW - Male

KW - Parkinsonian Disorders

KW - Time Factors

U2 - 10.1016/j.nbd.2009.05.018

DO - 10.1016/j.nbd.2009.05.018

M3 - Journal article

C2 - 19501164

SN - 0969-9961

VL - 35

SP - 348

EP - 351

JO - Neurobiology of Disease

JF - Neurobiology of Disease

IS - 3

ER -

The blood-brain barrier is intact after levodopa-induced dyskinesias in parkinsonian primates--evidence from in vivo neuroimaging studies

Abstract

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