The birth weight lowering C-allele of rs900400 near LEKR1 and CCNL1 associates with elevated insulin release following an oral glucose challenge

Ehm Astrid Andersson; Marie Neergaard Harder; Kasper Pilgaard; Charlotta Pisinger; Alena Stančáková; Johanna Kuusisto; Niels Grarup; Kristine Færch; Pernille Hasse Busk Poulsen; Daniel Rinse Witte; Torben Jørgensen; Allan Vaag; Markku Laakso; Oluf Borbye Pedersen; Torben Hansen

doi:10.1371/journal.pone.0027096

The birth weight lowering C-allele of rs900400 near LEKR1 and CCNL1 associates with elevated insulin release following an oral glucose challenge

Ehm Astrid Andersson, Marie Neergaard Harder, Kasper Pilgaard, Charlotta Pisinger, Alena Stančáková, Johanna Kuusisto, Niels Grarup, Kristine Færch, Pernille Hasse Busk Poulsen, Daniel Rinse Witte, Torben Jørgensen, Allan Vaag, Markku Laakso, Oluf Borbye Pedersen, Torben Hansen

9 Citationer (Scopus)

Abstrakt

The first genome-wide association study on birth weight was recently published and the most significant associated birth weight lowering variant was the rs900400 C-allele located near LEKR1 and CCNL1. We aimed to replicate the association with birth weight in the Danish Inter99 study and furthermore to evaluate associations between rs900400 and indices of insulin secretion and insulin sensitivity obtained by oral glucose tolerance tests in adults from the Danish Inter99 study and the Finnish, Metabolic Syndrome in Men (METSIM) sample.

Originalsprog	Engelsk
Tidsskrift	P L o S One
Vol/bind	6
Udgave nummer	11
Sider (fra-til)	e27096
ISSN	1932-6203
DOI	https://doi.org/10.1371/journal.pone.0027096
Status	Udgivet - 2011

Adgang til dokumentet

10.1371/journal.pone.0027096

Citationsformater

Andersson, E. A., Harder, M. N., Pilgaard, K., Pisinger, C., Stančáková, A., Kuusisto, J., Grarup, N., Færch, K., Poulsen, P. H. B., Witte, D. R., Jørgensen, T., Vaag, A., Laakso, M., Pedersen, O. B., & Hansen, T. (2011). The birth weight lowering C-allele of rs900400 near LEKR1 and CCNL1 associates with elevated insulin release following an oral glucose challenge. P L o S One, 6(11), e27096. https://doi.org/10.1371/journal.pone.0027096

Andersson, EA, Harder, MN, Pilgaard, K, Pisinger, C, Stančáková, A, Kuusisto, J, Grarup, N, Færch, K, Poulsen, PHB, Witte, DR, Jørgensen, T , Vaag, A, Laakso, M, Pedersen, OB & Hansen, T 2011, 'The birth weight lowering C-allele of rs900400 near LEKR1 and CCNL1 associates with elevated insulin release following an oral glucose challenge', P L o S One, bind 6, nr. 11, s. e27096. https://doi.org/10.1371/journal.pone.0027096

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title = "The birth weight lowering C-allele of rs900400 near LEKR1 and CCNL1 associates with elevated insulin release following an oral glucose challenge",

abstract = "The first genome-wide association study on birth weight was recently published and the most significant associated birth weight lowering variant was the rs900400 C-allele located near LEKR1 and CCNL1. We aimed to replicate the association with birth weight in the Danish Inter99 study and furthermore to evaluate associations between rs900400 and indices of insulin secretion and insulin sensitivity obtained by oral glucose tolerance tests in adults from the Danish Inter99 study and the Finnish, Metabolic Syndrome in Men (METSIM) sample.",

author = "Andersson, {Ehm Astrid} and Harder, {Marie Neergaard} and Kasper Pilgaard and Charlotta Pisinger and Alena Stan{\v c}{\'a}kov{\'a} and Johanna Kuusisto and Niels Grarup and Kristine F{\ae}rch and Poulsen, {Pernille Hasse Busk} and Witte, {Daniel Rinse} and Torben J{\o}rgensen and Allan Vaag and Markku Laakso and Pedersen, {Oluf Borbye} and Torben Hansen",

year = "2011",

doi = "10.1371/journal.pone.0027096",

language = "English",

volume = "6",

pages = "e27096",

journal = "PLOS ONE",

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TY - JOUR

T1 - The birth weight lowering C-allele of rs900400 near LEKR1 and CCNL1 associates with elevated insulin release following an oral glucose challenge

AU - Andersson, Ehm Astrid

AU - Harder, Marie Neergaard

AU - Pilgaard, Kasper

AU - Pisinger, Charlotta

AU - Stančáková, Alena

AU - Kuusisto, Johanna

AU - Grarup, Niels

AU - Færch, Kristine

AU - Poulsen, Pernille Hasse Busk

AU - Witte, Daniel Rinse

AU - Jørgensen, Torben

AU - Vaag, Allan

AU - Laakso, Markku

AU - Pedersen, Oluf Borbye

AU - Hansen, Torben

PY - 2011

Y1 - 2011

N2 - The first genome-wide association study on birth weight was recently published and the most significant associated birth weight lowering variant was the rs900400 C-allele located near LEKR1 and CCNL1. We aimed to replicate the association with birth weight in the Danish Inter99 study and furthermore to evaluate associations between rs900400 and indices of insulin secretion and insulin sensitivity obtained by oral glucose tolerance tests in adults from the Danish Inter99 study and the Finnish, Metabolic Syndrome in Men (METSIM) sample.

AB - The first genome-wide association study on birth weight was recently published and the most significant associated birth weight lowering variant was the rs900400 C-allele located near LEKR1 and CCNL1. We aimed to replicate the association with birth weight in the Danish Inter99 study and furthermore to evaluate associations between rs900400 and indices of insulin secretion and insulin sensitivity obtained by oral glucose tolerance tests in adults from the Danish Inter99 study and the Finnish, Metabolic Syndrome in Men (METSIM) sample.

U2 - 10.1371/journal.pone.0027096

DO - 10.1371/journal.pone.0027096

M3 - Journal article

C2 - 22073261

VL - 6

SP - e27096

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 11

ER -

The birth weight lowering C-allele of rs900400 near LEKR1 and CCNL1 associates with elevated insulin release following an oral glucose challenge

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