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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

The background and philosophy behind daylight photodynamic therapy

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  1. Optimal sunscreen use, during a sun holiday with a very high ultraviolet index, allows vitamin D synthesis without sunburn

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Daylight PDT acts by continuous activation of PpIX

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  3. Serum 25(OH)D levels after oral vitamin D3 supplementation and UVB exposure correlate

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Conventional photodynamic therapy (PDT) is associated with side effects, primarily related to the waiting time between pretreatment with application of photosensitizer and illumination. Pain during illumination is a major issue for the patients and options for effective pain relief are limited. Post-treatment inflammation can often be severe and cause inconvenient down-time for the patients and their employers. To avoid the problems of pain and patients crowding in the clinic we eliminated red light treatment of high PpIX concentration and introduced illumination in daylight which may be performed at home. We also investigated if protoporphyrin IX (PpIX) could be activated continuously during its formation which might reduce pain and inflammation. Continuous activation of PpIX during its formation turned out to minimize pain as single PpIX molecules are activated continuously without accumulation of PpIX in the skin. PpIX molecules are formed in the mitochondria and the photodynamic effect only takes place in the mitochondria when continuously activated. This results primarily in apoptosis with little inflammation. Continuous activation of PpIX can be obtained by performing photodynamic therapy in daylight, as well as with daylight-emitting light sources of appropriate wavelengths. Use of daylight prevents the patients from crowding in the clinic. Daylight-PDT completely fulfils the purpose of minimizing pain and inflammation, as well as limiting the strain on the clinic treating the patients.

OriginalsprogEngelsk
TidsskriftGiornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia
Vol/bind153
Udgave nummer6
Sider (fra-til)776-782
Antal sider7
ISSN0392-0488
DOI
StatusUdgivet - dec. 2018

ID: 56141364