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The Association of MRI Findings and Long-Term Disability in Patients With Chronic Low Back Pain

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@article{160806eb440d418bab44f77846ccfa49,
title = "The Association of MRI Findings and Long-Term Disability in Patients With Chronic Low Back Pain",
abstract = "STUDY DESIGN: Longitudinal cohort study with 13-year follow-up.OBJECTIVE: To assess whether long-term disability is associated with baseline degenerative magnetic resonance imaging (MRI) findings in patients with low back pain (LBP).METHODS: In 2004-2005, patients aged 18 to 60 years with chronic LBP were enrolled in a randomized controlled trial and lumbar MRI was performed. Patients completed the Roland-Morris Disability Questionnaire (RMDQ) and the LBP Rating Scale, at baseline and 13 years after the MRI. Multivariate regression analysis was performed with 13-year RMDQ as the dependent variable and baseline disc degeneration (DD, Pfirrmann grade), Modic changes (MC), facet joint degeneration (FJD, Fujiwara grade) smoking status, body mass index, and self-reported weekly physical activity at leisure as independent variables.RESULTS: Of 204 patients with baseline MRI, 170 (83%) were available for follow-up. Of these, 88 had Pfirrmann grade >III (52%), 67 had MC (39%) and 139 had Fujiwara grade >2 (82%) on at least 1 lumbar level. Only MC (β = -0.15, P = .031) and weekly physical activity at leisure (β = -0.51, P < .001) were significantly, negatively, associated with 13-year RMDQ-score (R2 = 0.31).CONCLUSION: DD and FJD were not associated with long-term disability. Baseline MC and weekly physical activity at leisure were statistically significantly associated with less long-term disability.",
keywords = "MRI, Modic changes, degeneration, disability, long-term follow-up, low back pain (LBP)",
author = "Udby, {Peter Muhareb} and S{\o}ren Ohrt-Nissen and Tom Bendix and Stig Brorson and Carreon, {Leah Y} and Andersen, {Mikkel {\O}sterheden}",
year = "2021",
month = jun,
doi = "10.1177/2192568220921391",
language = "English",
volume = "11",
pages = "633--639",
journal = "Global Spine Journal",
issn = "2192-5682",
publisher = "GeorgThieme Verlag",
number = "5",

}

RIS

TY - JOUR

T1 - The Association of MRI Findings and Long-Term Disability in Patients With Chronic Low Back Pain

AU - Udby, Peter Muhareb

AU - Ohrt-Nissen, Søren

AU - Bendix, Tom

AU - Brorson, Stig

AU - Carreon, Leah Y

AU - Andersen, Mikkel Østerheden

PY - 2021/6

Y1 - 2021/6

N2 - STUDY DESIGN: Longitudinal cohort study with 13-year follow-up.OBJECTIVE: To assess whether long-term disability is associated with baseline degenerative magnetic resonance imaging (MRI) findings in patients with low back pain (LBP).METHODS: In 2004-2005, patients aged 18 to 60 years with chronic LBP were enrolled in a randomized controlled trial and lumbar MRI was performed. Patients completed the Roland-Morris Disability Questionnaire (RMDQ) and the LBP Rating Scale, at baseline and 13 years after the MRI. Multivariate regression analysis was performed with 13-year RMDQ as the dependent variable and baseline disc degeneration (DD, Pfirrmann grade), Modic changes (MC), facet joint degeneration (FJD, Fujiwara grade) smoking status, body mass index, and self-reported weekly physical activity at leisure as independent variables.RESULTS: Of 204 patients with baseline MRI, 170 (83%) were available for follow-up. Of these, 88 had Pfirrmann grade >III (52%), 67 had MC (39%) and 139 had Fujiwara grade >2 (82%) on at least 1 lumbar level. Only MC (β = -0.15, P = .031) and weekly physical activity at leisure (β = -0.51, P < .001) were significantly, negatively, associated with 13-year RMDQ-score (R2 = 0.31).CONCLUSION: DD and FJD were not associated with long-term disability. Baseline MC and weekly physical activity at leisure were statistically significantly associated with less long-term disability.

AB - STUDY DESIGN: Longitudinal cohort study with 13-year follow-up.OBJECTIVE: To assess whether long-term disability is associated with baseline degenerative magnetic resonance imaging (MRI) findings in patients with low back pain (LBP).METHODS: In 2004-2005, patients aged 18 to 60 years with chronic LBP were enrolled in a randomized controlled trial and lumbar MRI was performed. Patients completed the Roland-Morris Disability Questionnaire (RMDQ) and the LBP Rating Scale, at baseline and 13 years after the MRI. Multivariate regression analysis was performed with 13-year RMDQ as the dependent variable and baseline disc degeneration (DD, Pfirrmann grade), Modic changes (MC), facet joint degeneration (FJD, Fujiwara grade) smoking status, body mass index, and self-reported weekly physical activity at leisure as independent variables.RESULTS: Of 204 patients with baseline MRI, 170 (83%) were available for follow-up. Of these, 88 had Pfirrmann grade >III (52%), 67 had MC (39%) and 139 had Fujiwara grade >2 (82%) on at least 1 lumbar level. Only MC (β = -0.15, P = .031) and weekly physical activity at leisure (β = -0.51, P < .001) were significantly, negatively, associated with 13-year RMDQ-score (R2 = 0.31).CONCLUSION: DD and FJD were not associated with long-term disability. Baseline MC and weekly physical activity at leisure were statistically significantly associated with less long-term disability.

KW - MRI

KW - Modic changes

KW - degeneration

KW - disability

KW - long-term follow-up

KW - low back pain (LBP)

U2 - 10.1177/2192568220921391

DO - 10.1177/2192568220921391

M3 - Journal article

C2 - 32875907

VL - 11

SP - 633

EP - 639

JO - Global Spine Journal

JF - Global Spine Journal

SN - 2192-5682

IS - 5

ER -

ID: 62387075