TY - JOUR
T1 - The association between Staphylococcus aureus colonization on cheek skin at 2 months and subsequent atopic dermatitis in a prospective birth cohort
AU - Rinnov, Maria Rasmussen
AU - Gerner, Trine
AU - Halling, Anne-Sofie
AU - Liljendahl, Mie Sylow
AU - Ravn, Nina Haarup
AU - Knudgaard, Mette Hjorslev
AU - Trautner, Simon
AU - Skov, Lone
AU - Thomsen, Simon Francis
AU - Egeberg, Alexander
AU - Jakasa, Ivone
AU - Kezic, Sanja
AU - Petersen, Andreas
AU - Larsen, Anders Rhod
AU - Dam-Nielsen, Casper
AU - Jarløv, Jens Otto
AU - Thyssen, Jacob P
N1 - © The Author(s) 2023. Published by Oxford University Press on behalf of British Association of Dermatologists. All rights reserved. For permissions, please e-mail: [email protected].
PY - 2023/11/16
Y1 - 2023/11/16
N2 - BACKGROUND: Staphylococcus aureus may worsen already established atopic dermatitis (AD), but its primary role in the aetiopathogenesis and severity of AD is unclear.OBJECTIVES: To compare the prevalence of S. aureus colonization in early infancy in children who developed AD during the first 2 years of life with children who did not.METHODS: In this prospective birth cohort study, which included 450 infants, we analysed bacterial swabs collected from cheek skin at 0 and 2 months of age. The development of AD, and its severity, was diagnosed by a physician and monitored prospectively for 2 years. Information on parental atopy, filaggrin gene mutation status and use of antibiotics and emollients was included in the analyses.RESULTS: At birth, the occurrence of S. aureus colonization was similar in infants who developed subsequent AD and those who did not. At 2 months of age, S. aureus colonization was more common in children who later developed AD (adjusted hazard ratio 1.97, 95% confidence interval 1.21-3.19; P = 0.006). No association was found between S. aureus colonization and AD severity or age at onset.CONCLUSIONS: It remains unknown whether colonization with S. aureus may directly increase the risk of AD, or whether it should be considered as secondary to skin barrier impairment or a skewed immune activity, but according to our findings, S. aureus colonization is more commonly increased at 2 months of age in children who later developed AD.
AB - BACKGROUND: Staphylococcus aureus may worsen already established atopic dermatitis (AD), but its primary role in the aetiopathogenesis and severity of AD is unclear.OBJECTIVES: To compare the prevalence of S. aureus colonization in early infancy in children who developed AD during the first 2 years of life with children who did not.METHODS: In this prospective birth cohort study, which included 450 infants, we analysed bacterial swabs collected from cheek skin at 0 and 2 months of age. The development of AD, and its severity, was diagnosed by a physician and monitored prospectively for 2 years. Information on parental atopy, filaggrin gene mutation status and use of antibiotics and emollients was included in the analyses.RESULTS: At birth, the occurrence of S. aureus colonization was similar in infants who developed subsequent AD and those who did not. At 2 months of age, S. aureus colonization was more common in children who later developed AD (adjusted hazard ratio 1.97, 95% confidence interval 1.21-3.19; P = 0.006). No association was found between S. aureus colonization and AD severity or age at onset.CONCLUSIONS: It remains unknown whether colonization with S. aureus may directly increase the risk of AD, or whether it should be considered as secondary to skin barrier impairment or a skewed immune activity, but according to our findings, S. aureus colonization is more commonly increased at 2 months of age in children who later developed AD.
UR - http://www.scopus.com/inward/record.url?scp=85178164093&partnerID=8YFLogxK
U2 - 10.1093/bjd/ljad249
DO - 10.1093/bjd/ljad249
M3 - Journal article
C2 - 37480337
SN - 0007-0963
VL - 189
SP - 695
EP - 701
JO - British Journal of Dermatology
JF - British Journal of Dermatology
IS - 6
ER -