The association between low-grade inflammation, iron status and nucleic acid oxidation in the elderly

Kasper Broedbaek, Volkert Dirk Siersma, Jon T Andersen, Morten Petersen, Shoaib Afzal, Brian Hjelvang, Allan Weimann, Richard D Semba, Luigi Ferrucci, Henrik E Poulsen

19 Citationer (Scopus)

Abstract

This study applied a case-control approach to investigate the association between low-grade inflammation, defined by high values within the normal range of C-reactive protein (CRP) and interleukin-6 (IL-6), and urinary markers of nucleic acid oxidation. No differences in excretion of urinary markers of nucleic acid oxidation between cases and controls were found and multivariable linear regression analysis showed no association between urinary markers of nucleic acid oxidation and inflammatory markers. Post-hoc multivariable linear regression analysis showed significant associations between nucleic acid oxidation and various iron status markers and especially a close relationship between nucleic acid oxidation and ferritin. This study shows no association between low-grade inflammation and urinary markers of nucleic acid oxidation in a population of elderly Italian people. The results suggest that low-grade inflammation only has a negligible impact on whole body nucleic acid oxidation, whereas iron status seems to be of great importance.
OriginalsprogEngelsk
TidsskriftFree Radical Research
Vol/bind45
Udgave nummer4
Sider (fra-til)409-16
Antal sider8
ISSN1071-5762
DOI
StatusUdgivet - 1 apr. 2011

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