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Udgivet

The Apolipoprotein M/S1P Axis Controls Triglyceride Metabolism and Brown Fat Activity

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  2. Single mRNP Analysis Reveals that Small Cytoplasmic mRNP Granules Represent mRNA Singletons

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  3. Nodal Signaling Regulates Germ Cell Development and Establishment of Seminiferous Cords in the Human Fetal Testis

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  4. Gamma-Aminobutyric Acid Signaling in Brown Adipose Tissue Promotes Systemic Metabolic Derangement in Obesity

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  1. Relation of cardiac adipose tissue to coronary calcification and myocardial microvascular function in type 1 and type 2 diabetes

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  2. Soluble Markers of Interleukin 1 Activation as Predictors of First-Time Myocardial Infarction in HIV-Infected Individuals

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  3. FDG-PET/CT in the surveillance of head and neck cancer following radiotherapy

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  4. Validity of biopsy-based drug effects in a diet-induced obese mouse model of biopsy-confirmed NASH

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Vis graf over relationer

Apolipoprotein M (apoM) is the carrier of sphingosine-1-phosphate (S1P) in plasma high-density lipoproteins. S1P is a bioactive lipid interacting with five receptors (S1P1-5). We show that lack of apoM in mice increases the amount of brown adipose tissue (BAT), accelerates the clearance of postprandial triglycerides, and protects against diet-induced obesity (i.e., a phenotype similar to that induced by cold exposure or β3-adrenergic stimulation). Moreover, the data suggest that the phenotype of apoM-deficient mice is S1P dependent and reflects diminished S1P1 stimulation. The results reveal a link between the apoM/S1P axis and energy metabolism.

OriginalsprogEngelsk
TidsskriftCell Reports
Vol/bind22
Udgave nummer1
Sider (fra-til)175-188
Antal sider14
DOI
StatusUdgivet - 2 jan. 2018

ID: 55063964