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Udgivet

The Apolipoprotein M/S1P Axis Controls Triglyceride Metabolism and Brown Fat Activity

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  1. Nodal Signaling Regulates Germ Cell Development and Establishment of Seminiferous Cords in the Human Fetal Testis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Gamma-Aminobutyric Acid Signaling in Brown Adipose Tissue Promotes Systemic Metabolic Derangement in Obesity

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  3. Differences in Cell Cycle Status Underlie Transcriptional Heterogeneity in the HSC Compartment

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  4. A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection

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  1. Cardiac Autonomic Function is Associated With Myocardial Flow Reserve in Type 1 Diabetes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Hyperpolarized 13C MRI: Path to Clinical Translation in Oncology

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  3. Feasibility of multi-parametric PET and MRI for prediction of tumour recurrence in patients with glioblastoma

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Vis graf over relationer

Apolipoprotein M (apoM) is the carrier of sphingosine-1-phosphate (S1P) in plasma high-density lipoproteins. S1P is a bioactive lipid interacting with five receptors (S1P1-5). We show that lack of apoM in mice increases the amount of brown adipose tissue (BAT), accelerates the clearance of postprandial triglycerides, and protects against diet-induced obesity (i.e., a phenotype similar to that induced by cold exposure or β3-adrenergic stimulation). Moreover, the data suggest that the phenotype of apoM-deficient mice is S1P dependent and reflects diminished S1P1 stimulation. The results reveal a link between the apoM/S1P axis and energy metabolism.

OriginalsprogEngelsk
TidsskriftCell Reports
Vol/bind22
Udgave nummer1
Sider (fra-til)175-188
Antal sider14
DOI
StatusUdgivet - 2 jan. 2018

ID: 55063964