The 2024 revisions of the McDonald criteria pose risk of multiple sclerosis overdiagnosis

Andrew J Solomon; John B Brodersen

doi:10.1038/s41582-025-01140-4

The 2024 revisions of the McDonald criteria pose risk of multiple sclerosis overdiagnosis

Andrew J Solomon^*
, John B Brodersen

^*Corresponding author af dette arbejde

Center for Kræft og Organsygdomme Rigshospitalet

6 Citationer (Scopus)

Abstract

The 2024 revisions of the McDonald criteria for multiple sclerosis for the first time permit diagnosis in asymptomatic people with MRI findings suggestive of multiple sclerosis pathology. Although these changes promise opportunities for earlier treatment and improved clinical outcomes, they present a new risk in the form of overdiagnosis.

Originalsprog	Engelsk
Tidsskrift	Nature Reviews Neurology
Vol/bind	21
Udgave nummer	12
Sider (fra-til)	659-660
Antal sider	2
ISSN	1759-4758
DOI	https://doi.org/10.1038/s41582-025-01140-4
Status	Udgivet - dec. 2025

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title = "The 2024 revisions of the McDonald criteria pose risk of multiple sclerosis overdiagnosis",

abstract = "The 2024 revisions of the McDonald criteria for multiple sclerosis for the first time permit diagnosis in asymptomatic people with MRI findings suggestive of multiple sclerosis pathology. Although these changes promise opportunities for earlier treatment and improved clinical outcomes, they present a new risk in the form of overdiagnosis.",

author = "Solomon, \{Andrew J\} and Brodersen, \{John B\}",

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AU - Brodersen, John B

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AB - The 2024 revisions of the McDonald criteria for multiple sclerosis for the first time permit diagnosis in asymptomatic people with MRI findings suggestive of multiple sclerosis pathology. Although these changes promise opportunities for earlier treatment and improved clinical outcomes, they present a new risk in the form of overdiagnosis.

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DO - 10.1038/s41582-025-01140-4

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JO - Nature Reviews Neurology

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The 2024 revisions of the McDonald criteria pose risk of multiple sclerosis overdiagnosis

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