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Region Hovedstaden - en del af Københavns Universitetshospital

β-Thalassemia heterozygote state detrimentally affects health expectation

Publikation: Bidrag til tidsskriftReviewForskningpeer review


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  • Luciano Graffeo
  • Angela Vitrano
  • Salvatore Scondotto
  • Gabriella Dardanoni
  • Walter Sebastiano Pollina Addario
  • Antonino Giambona
  • Massimiliano Sacco
  • Rosario Di Maggio
  • Disma Renda
  • Federico Taormina
  • Andrea Triveri
  • Massimo Attanasio
  • Christian Gluud
  • Aurelio Maggio
Vis graf over relationer

BACKGROUND: Thalassemia minor (Tm) individuals, are generally considered healthy. However, the prognosis of Tm individuals has not been extensively studied. The aim of this study was to evaluate the prognosis of Tm versus controls without β-thalassemia carrier state.

METHODS: A total of 26,006 individuals seeking thalassemia screening at the AOOR Villa Sofia-V. Cervello, Palermo (Italy) were retrospectively studied. Logistic penalised regression model was used to estimate risk of potential complications and survival techniques were used to study mortality.

RESULTS: We identified a total of 4943 Tm and 21,063 controls. Tm was associated with significantly higher risks of hospitalisation for cirrhosis (OR 1·94, 95% CI 1·30 to 2·90, p = 0·001), kidney disorders (OR 2·11, 95% CI 1·27 to 3·51, p = 0·004), cholelithiatis (OR 1·39, 95% CI 1·08 to 1·79, p = 0·010), and mood disorders (OR 2·08, 95% CI 1·15 to 3·75, p = 0·015). No statistically difference in life expectancy between thalassemia minor and control group was found (HR 1·090, 95% CI 0·777 to 1·555, p < 0·590; log-rank test p = .426).

CONCLUSION: This study shows that Tm affects the prognosis of Tm carriers regarding health expectation. Probably, iron overload and anaemia for several years may be at the basis of these effects.

TidsskriftEuropean Journal of Internal Medicine
Sider (fra-til)76-80
StatusUdgivet - 2018

ID: 54833048