Testicular biopsy in prepubertal boys: a worthwhile minor surgical procedure?

Alice Faure, Aurore Bouty, Mike O'Brien, Jorgen Thorup, John Hutson, Yves Heloury

    26 Citationer (Scopus)

    Abstract

    No consensus exists regarding the precise role of testicular biopsy in prepubertal boys, although it is considered useful for assessing the potential consequences of undescended testes on fertility. Current scientific knowledge indicates that surgeons should broaden indications for this procedure. For example, the use of immunohistochemical markers such as OCT/3-4, TSPY, Kit ligand (SCF) and ALPP (PLAP) has considerably facilitated the detection of germ cell tumour precursors, such as carcinoma in situ and/or gonadoblastoma. These markers are very important for evaluating malignancy risk in undervirilized patients with 46,XY disorders of sexual development. Testicular histology is also of considerable value in the prediction of both fertility potential and risk of cancer in individuals with undescended testes, particularly those with intraabdominal undescended testes. New possibilities for the preservation of fertility after gonadotoxic chemotherapy - even for prepubertal boys - are emerging. Cryopreservation of testicular tissue samples for the preservation of fertility - although still an experimental method at present - is appealing in this context. In our opinion, testicular biopsy in prepubertal boys is a minor procedure that can provide valuable information for predicting the risk of malignancy and fertility, and might be useful in fertility preservation in the near future.

    OriginalsprogEngelsk
    TidsskriftNature reviews. Urology
    Vol/bind13
    Udgave nummer3
    Sider (fra-til)141-50
    ISSN1759-4812
    DOI
    StatusUdgivet - 20 jan. 2016

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