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Temporal changes in cardiac function and cerebral blood flow during sequential postmenopausal hormone replacement.

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Sørensen, M B ; Fritz-Hansen, T ; Jensen, Henriette Hvide ; Pedersen, A T ; Højgaard, L ; Ottesen, B. / Temporal changes in cardiac function and cerebral blood flow during sequential postmenopausal hormone replacement. I: American Journal of Obstetrics and Gynecology. 2001 ; Bind 184, Nr. 2. s. 41-47.

Bibtex

@article{bbccd56ecb604456822554eee76be144,
title = "Temporal changes in cardiac function and cerebral blood flow during sequential postmenopausal hormone replacement.",
abstract = "OBJECTIVE: The purpose was to assess the temporal changes in cardiac function and cerebral blood flow during postmenopausal administration of estrogen with and without progestogen. STUDY DESIGN: Sixteen postmenopausal volunteers were assessed during estradiol plus sequential norethindrone acetate and placebo in two 12-week periods. Temporal changes were measured by magnetic resonance flow mapping 8 times. RESULTS: Systemic vascular resistance was reduced during estradiol (-6.9{\%}; P <.05), declined further during the addition of norethindrone acetate, and was accompanied by an increase in stroke volume (maximum increase, 5.2{\%}; P <.05) without fluid retention. Both systolic (-5 mm Hg; P =.03) and diastolic (-3 mm Hg; P =.03) blood pressure were reduced during estradiol. Cerebral blood flow was reduced after 9 weeks of hormone replacement therapy (-37 mL/min; P =.01) but increased to baseline after the addition of norethindrone acetate. CONCLUSIONS: Sequential hormone replacement therapy is associated with changes in cardiac function, which are of therapeutic potential in cardiovascular disorders. Sequential hormone replacement therapy exhibits an overall neutral effect on cerebral blood flow.",
author = "S{\o}rensen, {M B} and T Fritz-Hansen and Jensen, {Henriette Hvide} and Pedersen, {A T} and L H{\o}jgaard and B Ottesen",
year = "2001",
doi = "10.1067/mob.2001.108333",
language = "English",
volume = "184",
pages = "41--47",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby, Inc",
number = "2",

}

RIS

TY - JOUR

T1 - Temporal changes in cardiac function and cerebral blood flow during sequential postmenopausal hormone replacement.

AU - Sørensen, M B

AU - Fritz-Hansen, T

AU - Jensen, Henriette Hvide

AU - Pedersen, A T

AU - Højgaard, L

AU - Ottesen, B

PY - 2001

Y1 - 2001

N2 - OBJECTIVE: The purpose was to assess the temporal changes in cardiac function and cerebral blood flow during postmenopausal administration of estrogen with and without progestogen. STUDY DESIGN: Sixteen postmenopausal volunteers were assessed during estradiol plus sequential norethindrone acetate and placebo in two 12-week periods. Temporal changes were measured by magnetic resonance flow mapping 8 times. RESULTS: Systemic vascular resistance was reduced during estradiol (-6.9%; P <.05), declined further during the addition of norethindrone acetate, and was accompanied by an increase in stroke volume (maximum increase, 5.2%; P <.05) without fluid retention. Both systolic (-5 mm Hg; P =.03) and diastolic (-3 mm Hg; P =.03) blood pressure were reduced during estradiol. Cerebral blood flow was reduced after 9 weeks of hormone replacement therapy (-37 mL/min; P =.01) but increased to baseline after the addition of norethindrone acetate. CONCLUSIONS: Sequential hormone replacement therapy is associated with changes in cardiac function, which are of therapeutic potential in cardiovascular disorders. Sequential hormone replacement therapy exhibits an overall neutral effect on cerebral blood flow.

AB - OBJECTIVE: The purpose was to assess the temporal changes in cardiac function and cerebral blood flow during postmenopausal administration of estrogen with and without progestogen. STUDY DESIGN: Sixteen postmenopausal volunteers were assessed during estradiol plus sequential norethindrone acetate and placebo in two 12-week periods. Temporal changes were measured by magnetic resonance flow mapping 8 times. RESULTS: Systemic vascular resistance was reduced during estradiol (-6.9%; P <.05), declined further during the addition of norethindrone acetate, and was accompanied by an increase in stroke volume (maximum increase, 5.2%; P <.05) without fluid retention. Both systolic (-5 mm Hg; P =.03) and diastolic (-3 mm Hg; P =.03) blood pressure were reduced during estradiol. Cerebral blood flow was reduced after 9 weeks of hormone replacement therapy (-37 mL/min; P =.01) but increased to baseline after the addition of norethindrone acetate. CONCLUSIONS: Sequential hormone replacement therapy is associated with changes in cardiac function, which are of therapeutic potential in cardiovascular disorders. Sequential hormone replacement therapy exhibits an overall neutral effect on cerebral blood flow.

U2 - 10.1067/mob.2001.108333

DO - 10.1067/mob.2001.108333

M3 - Journal article

VL - 184

SP - 41

EP - 47

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 2

ER -

ID: 32557833