Telomere length predicts all-cause mortality in patients with type 1 diabetes

A S Astrup; Lise Tarnow; A Jorsal; Marianne Lajer; R Nzietchueng; A Benetos; Pia Rossing; H-H Parving

doi:10.1007/s00125-009-1542-1

Telomere length predicts all-cause mortality in patients with type 1 diabetes

A S Astrup, Lise Tarnow, A Jorsal, Marianne Lajer, R Nzietchueng, A Benetos, Pia Rossing, H-H Parving

63 Citationer (Scopus)

Abstrakt

Type 1 diabetic patients with diabetic nephropathy have increased mortality and morbidity compared with normoalbuminuric patients. Telomere length in proliferative cells is inversely related to the total number of cell divisions, and therefore to biological age. We aimed to evaluate differences in telomere length in patients with type 1 diabetes with or without diabetic nephropathy; we also evaluated the prognostic value of telomere length.

Originalsprog	Engelsk
Tidsskrift	Diabetologia
Vol/bind	53
Udgave nummer	1
Sider (fra-til)	45-8
Antal sider	4
ISSN	0012-186X
DOI	https://doi.org/10.1007/s00125-009-1542-1
Status	Udgivet - 1 jan. 2010

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10.1007/s00125-009-1542-1

Citationsformater

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abstract = "Type 1 diabetic patients with diabetic nephropathy have increased mortality and morbidity compared with normoalbuminuric patients. Telomere length in proliferative cells is inversely related to the total number of cell divisions, and therefore to biological age. We aimed to evaluate differences in telomere length in patients with type 1 diabetes with or without diabetic nephropathy; we also evaluated the prognostic value of telomere length.",

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T1 - Telomere length predicts all-cause mortality in patients with type 1 diabetes

AU - Astrup, A S

AU - Tarnow, Lise

AU - Jorsal, A

AU - Lajer, Marianne

AU - Nzietchueng, R

AU - Benetos, A

AU - Rossing, Pia

AU - Parving, H-H

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Type 1 diabetic patients with diabetic nephropathy have increased mortality and morbidity compared with normoalbuminuric patients. Telomere length in proliferative cells is inversely related to the total number of cell divisions, and therefore to biological age. We aimed to evaluate differences in telomere length in patients with type 1 diabetes with or without diabetic nephropathy; we also evaluated the prognostic value of telomere length.

AB - Type 1 diabetic patients with diabetic nephropathy have increased mortality and morbidity compared with normoalbuminuric patients. Telomere length in proliferative cells is inversely related to the total number of cell divisions, and therefore to biological age. We aimed to evaluate differences in telomere length in patients with type 1 diabetes with or without diabetic nephropathy; we also evaluated the prognostic value of telomere length.

U2 - 10.1007/s00125-009-1542-1

DO - 10.1007/s00125-009-1542-1

M3 - Journal article

C2 - 19802713

VL - 53

SP - 45

EP - 48

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

IS - 1

ER -

Telomere length predicts all-cause mortality in patients with type 1 diabetes

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