Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

T-cell immunity against cytomegalovirus in HIV infection and aging: relationships with inflammation, immune activation, and frailty

Publikation: Bidrag til tidsskriftReviewForskningpeer review

DOI

  1. Bacterial aggregate size determines phagocytosis efficiency of polymorphonuclear leukocytes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Defective interferon priming and impaired antiviral responses in a patient with an IRF7 variant and severe influenza

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Both aging and treated human immunodeficiency virus (HIV) infection are characterized by low-level chronic inflammation and immune activation which contribute to the development of age-related diseases, frailty, and early mortality. Chronic cytomegalovirus (CMV) infection is highly prevalent in older adults and HIV-infected populations. A number of studies have shown that CMV induces broad and strong T-cell responses in CMV-seropositive older adults and HIV-infected individuals. CMV infection rarely develops into clinical disease in immunocompetent individuals. However, a large body of literature has shown adverse effects of chronic CMV infection on the health and longevity of these populations. It has been hypothesized that chronic CMV infection may be a driver of chronic inflammation and immune activation, and may further contribute to the development of frailty. Thus, there is a need to better understand the extent of the impact of chronic CMV infection on T-cell immunity and health in aging and HIV infection. In this review, we will address important considerations and challenges in the assessment of chronic CMV infection and CMV-specific T-cell responses. We will then review recent data on relationships between T-cell responses to CMV and levels of inflammatory markers and immune activation, as well as the onset of frailty.

OriginalsprogEngelsk
TidsskriftMedical Microbiology and Immunology
Vol/bind208
Udgave nummer3-4
Sider (fra-til)289-294
Antal sider6
ISSN0300-8584
DOI
StatusUdgivet - aug. 2019

ID: 56892117