TBscore II: Refining and validating a simple clinical score for treatment monitoring of patients with pulmonary tuberculosis

Frauke Rudolf, Grethe Lemvik, Ebba Abate, Jay Verkuilen, Thomas Schön, Victor Francisco Gomes, Jesper Eugen-Olsen, Lars Ostergaard, Christian Wejse

45 Citationer (Scopus)

Abstract

Abstract Background: The TBscore, based on simple signs and symptoms, was introduced to predict unsuccessful outcome in tuberculosis patients on treatment. A recent inter-observer variation study showed profound variation in some variables. Further, some variables depend on a physician assessing them, making the score less applicable. The aim of the present study was to simplify the TBscore. Methods: Inter-observer variation assessment and exploratory factor analysis were combined to develop a simplified score, the TBscore II. To validate TBscore II we assessed the association between start score and failure (i.e. death or treatment failure), responsiveness using Cohen's effect size, and the relationship between severity class at treatment start and a decrease
OriginalsprogEngelsk
TidsskriftScandinavian Journal of Infectious Diseases
Vol/bind45
Udgave nummer11
Sider (fra-til)825-36
Antal sider12
ISSN0036-5548
DOI
StatusUdgivet - nov. 2013

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