Targeting Cancer Lysosomes with Good Old Cationic Amphiphilic Drugs

Anne Marie Ellegaard, Peter Bach, Marja Jäättelä*

*Corresponding author af dette arbejde
10 Citationer (Scopus)

Abstract

Being originally discovered as cellular recycling bins, lysosomes are today recognized as versatile signaling organelles that control a wide range of cellular functions that are essential not only for the well-being of normal cells but also for malignant transformation and cancer progression. In addition to their core functions in waste disposal and recycling of macromolecules and energy, lysosomes serve as an indispensable support system for malignant phenotype by promoting cell growth, cytoprotective autophagy, drug resistance, pH homeostasis, invasion, metastasis, and genomic integrity. On the other hand, malignant transformation reduces the stability of lysosomal membranes rendering cancer cells sensitive to lysosome-dependent cell death. Notably, many clinically approved cationic amphiphilic drugs widely used for the treatment of other diseases accumulate in lysosomes, interfere with their cancer-promoting and cancer-supporting functions and destabilize their membranes thereby opening intriguing possibilities for cancer therapy. Here, we review the emerging evidence that supports the supplementation of current cancer therapies with lysosome-targeting cationic amphiphilic drugs.

OriginalsprogEngelsk
TitelReviews of Physiology, Biochemistry and Pharmacology
Antal sider46
Vol/bind185
ForlagSpringer Science and Business Media Deutschland GmbH
Publikationsdatojan. 2021
Sider107-152
DOI
StatusUdgivet - jan. 2021
NavnReviews of physiology, biochemistry and pharmacology
Vol/bind185
ISSN0303-4240

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