Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial

Jayant S Vaidya; David J Joseph; Jeffrey S Tobias; Max Bulsara; Frederik Wenz; Christobel Saunders; Michael Alvarado; Henrik L Flyger; Samuele Massarut; Wolfgang Eiermann; Mohammed Keshtgar; John Dewar; Uta Kraus-Tiefenbacher; Marc Sütterlin; Laura Esserman; Helle M R Holtveg; Mario Roncadin; Steffi Pigorsch; Marinos Metaxas; Mary Falzon; April Matthews; Tammy Corica; Norman R Williams; Michael Baum

doi:10.1016/S0140-6736(10)60837-9

Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial

Jayant S Vaidya, David J Joseph, Jeffrey S Tobias, Max Bulsara, Frederik Wenz, Christobel Saunders, Michael Alvarado, Henrik L Flyger, Samuele Massarut, Wolfgang Eiermann, Mohammed Keshtgar, John Dewar, Uta Kraus-Tiefenbacher, Marc Sütterlin, Laura Esserman, Helle M R Holtveg, Mario Roncadin, Steffi Pigorsch, Marinos Metaxas, Mary FalzonApril Matthews, Tammy Corica, Norman R Williams, Michael Baum

676 Citationer (Scopus)

Abstract

After breast-conserving surgery, 90% of local recurrences occur within the index quadrant despite the presence of multicentric cancers elsewhere in the breast. Thus, restriction of radiation therapy to the tumour bed during surgery might be adequate for selected patients. We compared targeted intraoperative radiotherapy with the conventional policy of whole breast external beam radiotherapy.

Originalsprog	Engelsk
Tidsskrift	Lancet
Vol/bind	376
Udgave nummer	9735
Sider (fra-til)	91-102
Antal sider	12
DOI	https://doi.org/10.1016/S0140-6736(10)60837-9
Status	Udgivet - 10 jul. 2010

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Vaidya, J. S., Joseph, D. J., Tobias, J. S., Bulsara, M., Wenz, F., Saunders, C., Alvarado, M., Flyger, H. L., Massarut, S., Eiermann, W., Keshtgar, M., Dewar, J., Kraus-Tiefenbacher, U., Sütterlin, M., Esserman, L., Holtveg, H. M. R., Roncadin, M., Pigorsch, S., Metaxas, M., ... Baum, M. (2010). Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial. Lancet, 376(9735), 91-102. https://doi.org/10.1016/S0140-6736(10)60837-9

Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial. / Vaidya, Jayant S; Joseph, David J; Tobias, Jeffrey S et al.
I: Lancet, Bind 376, Nr. 9735, 10.07.2010, s. 91-102.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Vaidya, JS, Joseph, DJ, Tobias, JS, Bulsara, M, Wenz, F, Saunders, C, Alvarado, M, Flyger, HL, Massarut, S, Eiermann, W, Keshtgar, M, Dewar, J, Kraus-Tiefenbacher, U, Sütterlin, M, Esserman, L, Holtveg, HMR, Roncadin, M, Pigorsch, S, Metaxas, M, Falzon, M, Matthews, A, Corica, T, Williams, NR & Baum, M 2010, 'Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial', Lancet, bind 376, nr. 9735, s. 91-102. https://doi.org/10.1016/S0140-6736(10)60837-9

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title = "Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial",

abstract = "After breast-conserving surgery, 90\% of local recurrences occur within the index quadrant despite the presence of multicentric cancers elsewhere in the breast. Thus, restriction of radiation therapy to the tumour bed during surgery might be adequate for selected patients. We compared targeted intraoperative radiotherapy with the conventional policy of whole breast external beam radiotherapy.",

author = "Vaidya, \{Jayant S\} and Joseph, \{David J\} and Tobias, \{Jeffrey S\} and Max Bulsara and Frederik Wenz and Christobel Saunders and Michael Alvarado and Flyger, \{Henrik L\} and Samuele Massarut and Wolfgang Eiermann and Mohammed Keshtgar and John Dewar and Uta Kraus-Tiefenbacher and Marc S{\"u}tterlin and Laura Esserman and Holtveg, \{Helle M R\} and Mario Roncadin and Steffi Pigorsch and Marinos Metaxas and Mary Falzon and April Matthews and Tammy Corica and Williams, \{Norman R\} and Michael Baum",

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doi = "10.1016/S0140-6736(10)60837-9",

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AU - Vaidya, Jayant S

AU - Joseph, David J

AU - Tobias, Jeffrey S

AU - Bulsara, Max

AU - Wenz, Frederik

AU - Saunders, Christobel

AU - Alvarado, Michael

AU - Flyger, Henrik L

AU - Massarut, Samuele

AU - Eiermann, Wolfgang

AU - Keshtgar, Mohammed

AU - Dewar, John

AU - Kraus-Tiefenbacher, Uta

AU - Sütterlin, Marc

AU - Esserman, Laura

AU - Holtveg, Helle M R

AU - Roncadin, Mario

AU - Pigorsch, Steffi

AU - Metaxas, Marinos

AU - Falzon, Mary

AU - Matthews, April

AU - Corica, Tammy

AU - Williams, Norman R

AU - Baum, Michael

PY - 2010/7/10

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N2 - After breast-conserving surgery, 90% of local recurrences occur within the index quadrant despite the presence of multicentric cancers elsewhere in the breast. Thus, restriction of radiation therapy to the tumour bed during surgery might be adequate for selected patients. We compared targeted intraoperative radiotherapy with the conventional policy of whole breast external beam radiotherapy.

AB - After breast-conserving surgery, 90% of local recurrences occur within the index quadrant despite the presence of multicentric cancers elsewhere in the breast. Thus, restriction of radiation therapy to the tumour bed during surgery might be adequate for selected patients. We compared targeted intraoperative radiotherapy with the conventional policy of whole breast external beam radiotherapy.

UR - https://www.scopus.com/pages/publications/77955013406

U2 - 10.1016/S0140-6736(10)60837-9

DO - 10.1016/S0140-6736(10)60837-9

M3 - Journal article

C2 - 20570343

SN - 1474-547X

VL - 376

SP - 91

EP - 102

JO - Lancet

JF - Lancet

IS - 9735

ER -

Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial

Abstract

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