@article{084455e585894608b81e8275d20dd8db,
title = "Targeted delivery of alcohol-containing payloads with antibody-drug conjugates",
abstract = "We herein describe the cell-specific release of alcohol-containing payloads via a sulfatase-sensitive linker in antibody-drug conjugates (ADCs). The linker shows efficient sulfatase-mediated release and high stability in human and mouse plasma. In vitro evaluation demonstrates potent antigen dependent toxicity towards breast cancer cell lines.",
keywords = "Animals, Antineoplastic Agents/pharmacology, Ethanol, Humans, Immunoconjugates/pharmacology, Mice",
author = "Grier, {Katja E} and Hansen, {Anders H} and Haxvig, {Christina S} and Xin Li and Oliver Krigslund and Niels Behrendt and Engelholm, {Lars H} and Fabio Rossi and Sousa, {Bebiana C} and Harradence, {Grant J} and Nicolas Camper and Qvortrup, {Katrine M}",
year = "2023",
month = jun,
day = "8",
doi = "10.1039/d3cc01596c",
language = "English",
volume = "59",
pages = "7240--7242",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "47",
}