Target Temperature Management after out-of-hospital cardiac arrest--a randomized, parallel-group, assessor-blinded clinical trial--rationale and design

Niklas Nielsen; Jørn Wetterslev; Nawaf al-Subaie; Bertil Andersson; John Bro-Jeppesen; Gillian Bishop; Iole Brunetti; Julius Cranshaw; Tobias Cronberg; Kristin Edqvist; David Erlinge; Yvan Gasche; Guy Glover; Christian Hassager; Janneke Horn; Jan Hovdenes; Jesper Johnsson; Jesper Kjaergaard; Michael Kuiper; Jørund Langørgen; Lewis Macken; Louise Martinell; Patrik Martner; Thomas Pellis; Paolo Pelosi; Per Erik Petersen; Stefan Persson; Malin Rundgren; Manoj Saxena; Robert Svensson; Pascal Stammet; Anders Thorén; Johan Undén; Andrew Walden; Jesper Wallskog; Michael Wanscher; Matthew P Wise; Nicholas Wyon; Anders Aneman; Hans Friberg

doi:10.1016/j.ahj.2012.01.013

Target Temperature Management after out-of-hospital cardiac arrest--a randomized, parallel-group, assessor-blinded clinical trial--rationale and design

Niklas Nielsen, Jørn Wetterslev, Nawaf al-Subaie, Bertil Andersson, John Bro-Jeppesen, Gillian Bishop, Iole Brunetti, Julius Cranshaw, Tobias Cronberg, Kristin Edqvist, David Erlinge, Yvan Gasche, Guy Glover, Christian Hassager, Janneke Horn, Jan Hovdenes, Jesper Johnsson, Jesper Kjaergaard, Michael Kuiper, Jørund LangørgenLewis Macken, Louise Martinell, Patrik Martner, Thomas Pellis, Paolo Pelosi, Per Erik Petersen, Stefan Persson, Malin Rundgren, Manoj Saxena, Robert Svensson, Pascal Stammet, Anders Thorén, Johan Undén, Andrew Walden, Jesper Wallskog, Michael Wanscher, Matthew P Wise, Nicholas Wyon, Anders Aneman, Hans Friberg

Copenhagen Trial Unit Rigshospitalet

138 Citationer (Scopus)

Abstract

Experimental animal studies and previous randomized trials suggest an improvement in mortality and neurologic function with induced hypothermia after cardiac arrest. International guidelines advocate the use of a target temperature management of 32°C to 34°C for 12 to 24 hours after resuscitation from out-of-hospital cardiac arrest. A systematic review indicates that the evidence for recommending this intervention is inconclusive, and the GRADE level of evidence is low. Previous trials were small, with high risk of bias, evaluated select populations, and did not treat hyperthermia in the control groups. The optimal target temperature management strategy is not known.

Originalsprog	Engelsk
Tidsskrift	American Heart Journal
Vol/bind	163
Udgave nummer	4
Sider (fra-til)	541-8
Antal sider	8
ISSN	0002-8703
DOI	https://doi.org/10.1016/j.ahj.2012.01.013
Status	Udgivet - 2012

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10.1016/j.ahj.2012.01.013

Citationsformater

Nielsen, N., Wetterslev, J., al-Subaie, N., Andersson, B., Bro-Jeppesen, J., Bishop, G., Brunetti, I., Cranshaw, J., Cronberg, T., Edqvist, K., Erlinge, D., Gasche, Y., Glover, G., Hassager, C., Horn, J., Hovdenes, J., Johnsson, J., Kjaergaard, J., Kuiper, M., ... Friberg, H. (2012). Target Temperature Management after out-of-hospital cardiac arrest--a randomized, parallel-group, assessor-blinded clinical trial--rationale and design. American Heart Journal, 163(4), 541-8. https://doi.org/10.1016/j.ahj.2012.01.013

Nielsen, N, Wetterslev, J, al-Subaie, N, Andersson, B, Bro-Jeppesen, J, Bishop, G, Brunetti, I, Cranshaw, J, Cronberg, T, Edqvist, K, Erlinge, D, Gasche, Y, Glover, G, Hassager, C, Horn, J, Hovdenes, J, Johnsson, J, Kjaergaard, J, Kuiper, M, Langørgen, J, Macken, L, Martinell, L, Martner, P, Pellis, T, Pelosi, P, Petersen, PE, Persson, S, Rundgren, M, Saxena, M, Svensson, R, Stammet, P, Thorén, A, Undén, J, Walden, A, Wallskog, J, Wanscher, M, Wise, MP, Wyon, N, Aneman, A & Friberg, H 2012, 'Target Temperature Management after out-of-hospital cardiac arrest--a randomized, parallel-group, assessor-blinded clinical trial--rationale and design', American Heart Journal, bind 163, nr. 4, s. 541-8. https://doi.org/10.1016/j.ahj.2012.01.013

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abstract = "Experimental animal studies and previous randomized trials suggest an improvement in mortality and neurologic function with induced hypothermia after cardiac arrest. International guidelines advocate the use of a target temperature management of 32°C to 34°C for 12 to 24 hours after resuscitation from out-of-hospital cardiac arrest. A systematic review indicates that the evidence for recommending this intervention is inconclusive, and the GRADE level of evidence is low. Previous trials were small, with high risk of bias, evaluated select populations, and did not treat hyperthermia in the control groups. The optimal target temperature management strategy is not known.",

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author = "Niklas Nielsen and J{\o}rn Wetterslev and Nawaf al-Subaie and Bertil Andersson and John Bro-Jeppesen and Gillian Bishop and Iole Brunetti and Julius Cranshaw and Tobias Cronberg and Kristin Edqvist and David Erlinge and Yvan Gasche and Guy Glover and Christian Hassager and Janneke Horn and Jan Hovdenes and Jesper Johnsson and Jesper Kjaergaard and Michael Kuiper and J{\o}rund Lang{\o}rgen and Lewis Macken and Louise Martinell and Patrik Martner and Thomas Pellis and Paolo Pelosi and Petersen, {Per Erik} and Stefan Persson and Malin Rundgren and Manoj Saxena and Robert Svensson and Pascal Stammet and Anders Thor{\'e}n and Johan Und{\'e}n and Andrew Walden and Jesper Wallskog and Michael Wanscher and Wise, {Matthew P} and Nicholas Wyon and Anders Aneman and Hans Friberg",

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doi = "10.1016/j.ahj.2012.01.013",

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AU - Nielsen, Niklas

AU - Wetterslev, Jørn

AU - al-Subaie, Nawaf

AU - Andersson, Bertil

AU - Bro-Jeppesen, John

AU - Bishop, Gillian

AU - Brunetti, Iole

AU - Cranshaw, Julius

AU - Cronberg, Tobias

AU - Edqvist, Kristin

AU - Erlinge, David

AU - Gasche, Yvan

AU - Glover, Guy

AU - Hassager, Christian

AU - Horn, Janneke

AU - Hovdenes, Jan

AU - Johnsson, Jesper

AU - Kjaergaard, Jesper

AU - Kuiper, Michael

AU - Langørgen, Jørund

AU - Macken, Lewis

AU - Martinell, Louise

AU - Martner, Patrik

AU - Pellis, Thomas

AU - Pelosi, Paolo

AU - Petersen, Per Erik

AU - Persson, Stefan

AU - Rundgren, Malin

AU - Saxena, Manoj

AU - Svensson, Robert

AU - Stammet, Pascal

AU - Thorén, Anders

AU - Undén, Johan

AU - Walden, Andrew

AU - Wallskog, Jesper

AU - Wanscher, Michael

AU - Wise, Matthew P

AU - Wyon, Nicholas

AU - Aneman, Anders

AU - Friberg, Hans

PY - 2012

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AB - Experimental animal studies and previous randomized trials suggest an improvement in mortality and neurologic function with induced hypothermia after cardiac arrest. International guidelines advocate the use of a target temperature management of 32°C to 34°C for 12 to 24 hours after resuscitation from out-of-hospital cardiac arrest. A systematic review indicates that the evidence for recommending this intervention is inconclusive, and the GRADE level of evidence is low. Previous trials were small, with high risk of bias, evaluated select populations, and did not treat hyperthermia in the control groups. The optimal target temperature management strategy is not known.

KW - Body Temperature

KW - Humans

KW - Multicenter Studies as Topic

KW - Out-of-Hospital Cardiac Arrest

KW - Quality of Life

KW - Randomized Controlled Trials as Topic

KW - Research Design

KW - Treatment Outcome

U2 - 10.1016/j.ahj.2012.01.013

DO - 10.1016/j.ahj.2012.01.013

M3 - Journal article

C2 - 22520518

SN - 0002-8703

VL - 163

SP - 541

EP - 548

JO - American Heart Journal

JF - American Heart Journal

IS - 4

ER -

Target Temperature Management after out-of-hospital cardiac arrest--a randomized, parallel-group, assessor-blinded clinical trial--rationale and design

Abstract

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