Target Temperature Management after out-of-hospital cardiac arrest--a randomized, parallel-group, assessor-blinded clinical trial--rationale and design

Niklas Nielsen, Jørn Wetterslev, Nawaf al-Subaie, Bertil Andersson, John Bro-Jeppesen, Gillian Bishop, Iole Brunetti, Julius Cranshaw, Tobias Cronberg, Kristin Edqvist, David Erlinge, Yvan Gasche, Guy Glover, Christian Hassager, Janneke Horn, Jan Hovdenes, Jesper Johnsson, Jesper Kjaergaard, Michael Kuiper, Jørund LangørgenLewis Macken, Louise Martinell, Patrik Martner, Thomas Pellis, Paolo Pelosi, Per Erik Petersen, Stefan Persson, Malin Rundgren, Manoj Saxena, Robert Svensson, Pascal Stammet, Anders Thorén, Johan Undén, Andrew Walden, Jesper Wallskog, Michael Wanscher, Matthew P Wise, Nicholas Wyon, Anders Aneman, Hans Friberg

137 Citationer (Scopus)

Abstract

Experimental animal studies and previous randomized trials suggest an improvement in mortality and neurologic function with induced hypothermia after cardiac arrest. International guidelines advocate the use of a target temperature management of 32°C to 34°C for 12 to 24 hours after resuscitation from out-of-hospital cardiac arrest. A systematic review indicates that the evidence for recommending this intervention is inconclusive, and the GRADE level of evidence is low. Previous trials were small, with high risk of bias, evaluated select populations, and did not treat hyperthermia in the control groups. The optimal target temperature management strategy is not known.
OriginalsprogEngelsk
TidsskriftAmerican Heart Journal
Vol/bind163
Udgave nummer4
Sider (fra-til)541-8
Antal sider8
ISSN0002-8703
DOI
StatusUdgivet - 2012

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