T1D-lipidome: Database of lipidomic aberrations during the pathogenesis of type 1 diabetes (T1D)

2021 Update

The T1D Lipidome Database and the analysis was updated with
four new publications from 2020-21:

A Mediation Approach to Discovering Causal Relationships between the Metabolome and DNA Methylation in Type 1 Diabetes.
Tim Vigers, Lauren A. Vanderlinden, Randi K. Johnson, Patrick M. Carry, Ivana Yang, Brian C. DeFelice, Alexander M. Kaizer, Laura Pyle, Marian Rewers, Oliver Fiehn, Jill M. Norris, Katerina Kechris.
Metabolites. 2021; 11 (8) 542.
https://doi.org/10.3390/metabo11080542

Characterization of plasma lipidomics in adolescent subjects with increased risk for type 1 diabetes in the DiPiS cohort
Agnes Andersson Svärd, Simranjeet Kaur, Kajetan Trôst, Tommi Suvitaival, Åke Lernmark, Marlena Maziarz, Flemming Pociot, Anne Julie Overgaard, The DiPiS Study Group.
Metabolomics 16, 109 (2020).
https://doi.org/10.1007/s11306-020-01730-x

Longitudinal Metabolome-Wide Signals Prior to the Appearance of a First Islet Autoantibody in Children Participating in the TEDDY Study
Qian Li, Hemang Parikh, Martha D. Butterworth, Åke Lernmark, William Hagopian, Marian Rewers, Jin-Xiong She, Jorma Toppari, Anette-G. Ziegler, Beena Akolkar, Oliver Fiehn, Sili Fan, Jeffrey P. Krischer, the TEDDY Study Group.
Diabetes Mar 2020, 69 (3) 465-476; DOI: 10.2337/db19-0756
https://doi.org/10.2337/db19-0756

Plasma Metabolome and Circulating Vitamins Stratified Onset Age of an Initial Islet Autoantibody and Progression to Type 1 Diabetes: The TEDDY Study
Qian Li, Xiang Liu, Jimin Yang, Iris Erlund, Åke Lernmark, William Hagopian, Marian Rewers, Jin-Xiong She, Jorma Toppari, Anette-G. Ziegler, Beena Akolkar, Jeffrey P. Krischer, the TEDDY Study Group.
Diabetes Jan 2021, 70 (1) 282-292; DOI: 10.2337/db20-0696
https://doi.org/10.2337/db20-0696

--

Description

This is the living database of lipidomic aberrations during the pathogenesis of type 1 diabetes (T1D).

The database has been collected from scientific publications that report abnormalities related to the onset of T1D. In practice, this either means:

1. lipids that are aberrated in blood samples collected from persons, who are later known to have been diagnosed with T1D,
2. lipids that are aberrated in blood samples collected from persons, who are have islet auto-antibodies (IAA-positive), or
3. lipids that are associated with the deterioration of insulin secretion in blood samples collected from persons recently diagnosed with T1D.

This database is described in the following publication. Please cite the publication, if you use the database or related code:

Citation

Tommi Suvitaival. Lipidomic Abnormalities During the Pathogenesis of Type 1 Diabetes: a Quantitative Review. Current Diabetes Reports. 20, 46 (2020). http://dx.doi.org/10.1007/s11892-020-01326-8

Acknowledgement

This project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No 115797 (INNODIA). This Joint Undertaking receives support from the Union’s Horizon 2020 research and innovation programme and “EFPIA”, ‘JDRF” and “The Leona M. and Harry B. Helmsley Charitable Trust”.