T-lymphocytes transfer streptozotocin induced diabetes mellitus in mice

K Buschard, J Rygaard

Abstract

Diabetes mellitus induced by low dose treatment with streptozotocin in BALB/c mice was passively transferred to syngeneic recipients with a predominantly T-lymphocyte fraction of spleen cells. This fraction was prepared by density centrifugation and passage through an antimouse immunoglobulin coated column. Variation in numbers of injected cells in the range of 10(3) to 10(7) showed that the smaller cell numbers gave the highest blood sugar values. Athymic nude recipients of BALB/c background also developed diabetes following similar transplants. A preliminary result was that the highest blood sugars were seen after transplantation of T-lymphocytes treated by low dose irradiation (200 R). This may reflect a specific effect on T-suppressor lymphocytes.

OriginalsprogEngelsk
TidsskriftActa pathologica et microbiologica Scandinavica. Section C, Immunology
Vol/bind86C
Udgave nummer6
Sider (fra-til)277-82
Antal sider6
ISSN0304-1328
DOI
StatusUdgivet - dec. 1978
Udgivet eksterntJa

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