Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Systolic and Diastolic Function by Tissue Doppler Imaging Predicts Mortality in Patients with Atrial Fibrillation

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Soluble Urokinase Plasminogen Activator Receptor (suPAR) as a Predictor of Incident Atrial Fibrillation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Role of PR-Interval In Predicting the Occurrence of Atrial Fibrillation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. The Relationship between physical activity and risk of atrial fibrillation-A systematic review and meta-Analysis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Prognostic value of ratio of transmitral early filling velocity to early diastolic strain rate in patients with Type 2 diabetes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Utility of left atrial strain for predicting atrial fibrillation following ischemic stroke

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. An echocardiographic substrate for dyspnea identifies high risk patients with type 2 diabetes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. The association between physical activity and cardiac performance is dependent on age: the Copenhagen City Heart Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

AIM: Tissue Doppler Imaging (TDI) detects early signs of left ventricular dysfunction. The prognostic potential of TDI in patients with atrial fibrillation (AF) has, however, not yet been clarified. This study evaluates the prognostic value of TDI in patients with atrial fibrillation.

METHODS AND RESULTS: In total, echocardiograms from 313 patients with AF during examination were analyzed offline. Longitudinal systolic velocity (s'), early diastolic velocity (e') and longitudinal displacement (LD) were measured by color TDI. During a median follow-up of 891 days, 64 patients (20%) died. TDI was significantly associated with all-cause mortality, and the risk of dying increased significantly per 1 cm/s decrease in s' (HR of 1.31, 95% CI 1.05-1.63; p=0.018) and e' (HR of 1.17, 95% CI 1.01-1.35; p=0.038) respectively, even after adjustment for age, gender, heart rate, aortic stenosis, DM and LVEF quartiles. LD also proved to be a significant predictor of outcome after multivariate adjustment (HR 1.23; 95% CI 1.05-1.44; p=0.012). The population was stratified according to high or low s' and e'. Patients with low s' and e' had more than three times the risk of mortality compared to the patients with high s' and e' (HR 3.64; 95% CI 1.83-7.26; p<0.001) and remained in significantly higher risk after adjustment for various risk factors.

CONCLUSIONS: Both systolic and diastolic performance, as assessed by TDI, are strong predictors of mortality in patients with atrial fibrillation, and especially the combination of systolic and diastolic dysfunction is a significant prognostic marker.

OriginalsprogEngelsk
TidsskriftJournal of Atrial Fibrillation
Vol/bind8
Udgave nummer1
Sider (fra-til)e1241
ISSN1941-6911
DOI
StatusUdgivet - 30 jun. 2015

ID: 52828871