Systemic Lupus Erythematosus Risk: The Role of Environmental Factors

Jia Li Liu, Jennifer M.P. Woo, Christine G. Parks, Karen H. Costenbader, Søren Jacobsen, Sasha Bernatsky*

*Corresponding author af dette arbejde

Abstrakt

Systemic lupus erythematosus (SLE) is a complex, chronic autoimmune disease. The etiology of SLE is multifactorial and includes potential environmental triggers, which may occur sequentially (the "multi-hit" hypothesis). This review focuses on SLE risk potentially associated with environmental factors including infections, the microbiome, diet, respirable exposures (eg, crystalline silica, smoking, air pollution), organic pollutants, heavy metals, and ultraviolet radiation.

OriginalsprogEngelsk
TidsskriftRheumatic Disease Clinics of North America
Vol/bind48
Udgave nummer4
Sider (fra-til)827-843
Antal sider17
ISSN0889-857X
DOI
StatusUdgivet - 2022

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