Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Systematic review with meta-analysis: association of vitamin D status with clinical outcomes in adult patients with inflammatory bowel disease

Publikation: Bidrag til tidsskriftReviewpeer review

DOI

  1. Editorial: non-selective beta blockers-in and out of circulation

    Publikation: Bidrag til tidsskriftLederpeer review

  2. Antibiotics during childhood and development of appendicitis-a nationwide cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Fibrogenesis and inflammation contribute to the pathogenesis of cirrhotic cardiomyopathy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. All-cause and cause-specific mortality in microscopic colitis: a Danish nationwide matched cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. A fully defined 3D matrix for ex vivo expansion of human colonic organoids from biopsy tissue

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Mucosal vitamin D signaling in inflammatory bowel disease

    Publikation: Bidrag til tidsskriftReviewpeer review

  3. Telomere dysfunction activates YAP1 to drive tissue inflammation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: Vitamin D deficiency is highly prevalent among patients with IBD, however, data on its association with clinical outcomes are conflicting.

AIM: To perform a systematic review and meta-analysis to explore the association of low vitamin D status with clinical outcomes in patients with IBD.

METHODS: We searched PubMed, Embase, Scopus and Web of Science from inception to February 2018 for observational studies evaluating the association of low 25(OH)D status on IBD disease activity, mucosal inflammation, clinical relapse and quality of life. Odds ratios (ORs) were pooled and analysed using a random effects model.

RESULTS: Twenty-seven studies were eligible for inclusion comprising 8316 IBD patients (3115 ulcerative colitis, 5201 Crohn's disease). Among IBD patients, low 25(OH)D status was associated with increased odds of disease activity (OR 1.53, 95% CI 1.32-1.77, I2 = 0%), mucosal inflammation (OR 1.25, 95% CI 1.06-1.47, I2 = 0%), low quality of life (QOL) scores (OR 1.30, 95% CI 1.06-1.60, I2 = 0%) and future clinical relapse (OR 1.23, 95% CI 1.03-1.47, I2 = 0%). In subgroup analysis, low vitamin D status was associated with Crohn's disease activity (OR 1.66, 95% CI 1.36-2.03, I2 = 0%), mucosal inflammation (OR 1.39, 95% CI 1.03-1.85, I2 = 0%), clinical relapse (OR 1.35, 95% CI 1.14-1.59, I2 = 0%), and low QOL scores (OR 1.25, 95% CI 1.04-1.50, I2 = 0%) and ulcerative colitis disease activity (OR 1.47, 95% CI 1.03-2.09, I2 = 0%) and clinical relapse (OR 1.20, 95% 1.01-1.43, I2 = 0%).

CONCLUSIONS: Low 25(OH)D status is a biomarker for disease activity and predictor of poor clinical outcomes in IBD patients.

OriginalsprogEngelsk
TidsskriftAlimentary Pharmacology and Therapeutics
Vol/bind50
Udgave nummer11-12
Sider (fra-til)1146-1158
Antal sider13
ISSN0269-2813
DOI
StatusUdgivet - dec. 2019

Bibliografisk note

© 2019 John Wiley & Sons Ltd.

ID: 59003104