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Systematic review with meta-analysis: proximal disease extension in limited ulcerative colitis

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Roda, G, Narula, N, Pinotti, R, Skamnelos, A, Katsanos, KH, Ungaro, R, Burisch, J, Torres, J & Colombel, J-F 2017, 'Systematic review with meta-analysis: proximal disease extension in limited ulcerative colitis' Alimentary Pharmacology and Therapeutics, bind 45, nr. 12, s. 1481-1492. https://doi.org/10.1111/apt.14063

APA

Roda, G., Narula, N., Pinotti, R., Skamnelos, A., Katsanos, K. H., Ungaro, R., ... Colombel, J-F. (2017). Systematic review with meta-analysis: proximal disease extension in limited ulcerative colitis. Alimentary Pharmacology and Therapeutics, 45(12), 1481-1492. https://doi.org/10.1111/apt.14063

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Author

Roda, G ; Narula, N ; Pinotti, R ; Skamnelos, A ; Katsanos, K H ; Ungaro, R ; Burisch, J ; Torres, J ; Colombel, J-F. / Systematic review with meta-analysis : proximal disease extension in limited ulcerative colitis. I: Alimentary Pharmacology and Therapeutics. 2017 ; Bind 45, Nr. 12. s. 1481-1492.

Bibtex

@article{8a94e062e74b4a9f8c96225f9961bcee,
title = "Systematic review with meta-analysis: proximal disease extension in limited ulcerative colitis",
abstract = "BACKGROUND: Disease extent in ulcerative colitis is one of the major factors determining prognosis over the long-term. Disease extent is dynamic and a proportion of patients presenting with limited disease progress to more extensive forms of disease over time.AIM: To perform a systematic review and meta-analysis of epidemiological studies reporting on extension of ulcerative colitis to determine frequency of disease extension in patients with limited ulcerative colitis at diagnosis.METHODS: We performed a systematic literature search to identify studies on disease extension of ulcerative colitis (UC) and predictors of disease progression.RESULTS: Overall, 41 studies were eligible for systematic review but only 30 for meta-analysis. The overall pooled frequency of UC extension was 22.8{\%} with colonic extension being 17.8{\%} at 5 years and 31{\%} at 10 years. Extension was 17.8{\%} (95{\%} CI 11.2-27.3) from E1 to E3, 27.5{\%} (95{\%} CI 7.6-45.6) from E2 to E3 and 20.8{\%} (95{\%} CI 11.4-26.8) from E1 to E2. Rate of extension was significantly higher in patients younger than 18 years (29.2{\%} (CI 6.4-71.3) compared to older patients (20.2{\%} (CI 13.0-30.1) (P<.0001). Risk of extension was significantly higher in patients from North America (37.8{\%}) than from Europe (19.6{\%}) (P<.0001).CONCLUSIONS: In this meta-analysis, approximately one quarter of patients with limited UC extend over time with most extension occurring during the first 10 years. Rate of extension depends on age at diagnosis and geographic origin. Predicting those at high risk of disease extension from diagnosis could lead to personalised therapeutic strategies.",
keywords = "Adult, Colitis, Ulcerative, Disease Progression, Europe, Humans, Prognosis, Risk Factors, Journal Article, Meta-Analysis, Review",
author = "G Roda and N Narula and R Pinotti and A Skamnelos and Katsanos, {K H} and R Ungaro and J Burisch and J Torres and J-F Colombel",
note = "{\circledC} 2017 John Wiley & Sons Ltd.",
year = "2017",
month = "6",
doi = "10.1111/apt.14063",
language = "English",
volume = "45",
pages = "1481--1492",
journal = "Alimentary Pharmacology and Therapeutics",
issn = "0269-2813",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "12",

}

RIS

TY - JOUR

T1 - Systematic review with meta-analysis

T2 - proximal disease extension in limited ulcerative colitis

AU - Roda, G

AU - Narula, N

AU - Pinotti, R

AU - Skamnelos, A

AU - Katsanos, K H

AU - Ungaro, R

AU - Burisch, J

AU - Torres, J

AU - Colombel, J-F

N1 - © 2017 John Wiley & Sons Ltd.

PY - 2017/6

Y1 - 2017/6

N2 - BACKGROUND: Disease extent in ulcerative colitis is one of the major factors determining prognosis over the long-term. Disease extent is dynamic and a proportion of patients presenting with limited disease progress to more extensive forms of disease over time.AIM: To perform a systematic review and meta-analysis of epidemiological studies reporting on extension of ulcerative colitis to determine frequency of disease extension in patients with limited ulcerative colitis at diagnosis.METHODS: We performed a systematic literature search to identify studies on disease extension of ulcerative colitis (UC) and predictors of disease progression.RESULTS: Overall, 41 studies were eligible for systematic review but only 30 for meta-analysis. The overall pooled frequency of UC extension was 22.8% with colonic extension being 17.8% at 5 years and 31% at 10 years. Extension was 17.8% (95% CI 11.2-27.3) from E1 to E3, 27.5% (95% CI 7.6-45.6) from E2 to E3 and 20.8% (95% CI 11.4-26.8) from E1 to E2. Rate of extension was significantly higher in patients younger than 18 years (29.2% (CI 6.4-71.3) compared to older patients (20.2% (CI 13.0-30.1) (P<.0001). Risk of extension was significantly higher in patients from North America (37.8%) than from Europe (19.6%) (P<.0001).CONCLUSIONS: In this meta-analysis, approximately one quarter of patients with limited UC extend over time with most extension occurring during the first 10 years. Rate of extension depends on age at diagnosis and geographic origin. Predicting those at high risk of disease extension from diagnosis could lead to personalised therapeutic strategies.

AB - BACKGROUND: Disease extent in ulcerative colitis is one of the major factors determining prognosis over the long-term. Disease extent is dynamic and a proportion of patients presenting with limited disease progress to more extensive forms of disease over time.AIM: To perform a systematic review and meta-analysis of epidemiological studies reporting on extension of ulcerative colitis to determine frequency of disease extension in patients with limited ulcerative colitis at diagnosis.METHODS: We performed a systematic literature search to identify studies on disease extension of ulcerative colitis (UC) and predictors of disease progression.RESULTS: Overall, 41 studies were eligible for systematic review but only 30 for meta-analysis. The overall pooled frequency of UC extension was 22.8% with colonic extension being 17.8% at 5 years and 31% at 10 years. Extension was 17.8% (95% CI 11.2-27.3) from E1 to E3, 27.5% (95% CI 7.6-45.6) from E2 to E3 and 20.8% (95% CI 11.4-26.8) from E1 to E2. Rate of extension was significantly higher in patients younger than 18 years (29.2% (CI 6.4-71.3) compared to older patients (20.2% (CI 13.0-30.1) (P<.0001). Risk of extension was significantly higher in patients from North America (37.8%) than from Europe (19.6%) (P<.0001).CONCLUSIONS: In this meta-analysis, approximately one quarter of patients with limited UC extend over time with most extension occurring during the first 10 years. Rate of extension depends on age at diagnosis and geographic origin. Predicting those at high risk of disease extension from diagnosis could lead to personalised therapeutic strategies.

KW - Adult

KW - Colitis, Ulcerative

KW - Disease Progression

KW - Europe

KW - Humans

KW - Prognosis

KW - Risk Factors

KW - Journal Article

KW - Meta-Analysis

KW - Review

U2 - 10.1111/apt.14063

DO - 10.1111/apt.14063

M3 - Review

VL - 45

SP - 1481

EP - 1492

JO - Alimentary Pharmacology and Therapeutics

JF - Alimentary Pharmacology and Therapeutics

SN - 0269-2813

IS - 12

ER -

ID: 52417329